AIMC Topic: Radiotherapy Dosage

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Automatic lung dose painting for functional lung avoidance radiotherapy through multi-modality-guided dose prediction.

Physics in medicine and biology
This study aims to develop a multi-modality-guided dose prediction (MMDP)-based auto-planning algorithm for functional lung avoidance radiotherapy (FLART) guided by voxel-wise lung function images.The proposed auto-planning algorithm consists of a no...

Deep learning-based prediction of dynamic blood dose estimates for head-and-neck cancer.

Physics in medicine and biology
During radiotherapy, the radiation dose delivered to circulating blood can result in radiation-induced lymphopenia, which is correlated with adverse clinical outcomes like lower survival. Increasingly complex models to simulate radiation dose deliver...

Integrating aperture shape controller and machine learning prediction to improve gamma passing rates in lattice radiotherapy.

Physics in medicine and biology
This study proposes a workflow integrating the aperture shape controller (ASC) in the Varian Eclipse system with a machine learning-based verification prediction model to improve gamma passing rates (GPRs) of LATTICE Radiotherapy (LRT) plans and redu...

New insights into automatic treatment planning for cancer radiotherapy using explainable artificial intelligence.

Physics in medicine and biology
This study aims to uncover the opaque decision-making process of an artificial intelligence (AI) agent for automatic treatment planning.We examined a previously developed AI agent based on the actor-critic with experience replay (ACER) network, which...

Incorporating and quantifying deformable image registration uncertainties in dose accumulation: a feasibility study on the benefit of online adaptive therapy.

Physics in medicine and biology
. Accurate dose accumulation relies on deformable image registration (DIR) to track dose across multiple images. However, DIR introduces uncertainties that can impact cumulative dose distributions. In this study, we present a probabilistic framework ...

Neural network-driven direct CBCT-based dose calculation for head-and-neck proton treatment planning.

Physics in medicine and biology
Accurate dose calculation on cone beam computed tomography (CBCT) images is essential for modern proton treatment planning workflows, particularly when accounting for inter-fractional anatomical changes in adaptive treatment scenarios. Traditional CB...

Dose stratification-based convolutional neural networks for dose distribution prediction in radiotherapy.

Biomedical physics & engineering express
The fidelity of dose distribution prediction is paramount for radiotherapy planning. While existing deep learning-based methods have obtained noteworthy performance, most of them pursue the accurate prediction of global dose distribution but neglect ...

Impact of patient-specific deep learning lung organs-at-risk segmentation on accumulated dose in online adaptive 0.35 T MR-guided radiotherapy.

Physics in medicine and biology
Online adaptation in magnetic resonance imaging-guided radiotherapy (MRgRT) for lung cancer is hindered by time-consuming organs-at-risk (OARs) recontouring on daily MR images (dMRIs) and inter-/intra-observer variability. Deep learning auto-segmenta...

Dual-arc VMAT machine parameter optimization for localized prostate cancer using deep reinforcement learning.

Physics in medicine and biology
To develop and evaluate a deep reinforcement learning (RL) framework for rapid and automatic machine parameter optimization of volumetric modulated arc therapy (VMAT) treatment plans for localized prostate cancer.A multi-task policy network combining...

A comprehensive dose-volume histogram-based index for radiotherapy treatment plan quality evaluation: application to breast cancer radiotherapy.

Physics in medicine and biology
Advances in radiotherapy have increased treatment plan complexity, making manual quality evaluation more subjective and variable. While deep learning approaches offer automation in planning, evaluation remains a manual bottleneck. Existing indices ev...