In vitro anti-Trichomonas vaginalis activity of Haplophyllum myrtifolium.

Journal: Journal of infection in developing countries
PMID: 32040454

Abstract

INTRODUCTION: In the classic treatment of Trichomonas vaginalis infection, although metronidazole has been used since the 1960s, there has been an increase in MTZ-resistant T. vaginalis strains and failure in the treatment of trichomoniasis causes serious concerns. Therefore, the present study aimed to investigate the in vitro antitrichomonal activities of extracts (ethanol and total alkaloid) and pure compounds (chrysosplenetin, dictamnine, gamma-Fagarine, skimmianine) of H. myrtifolium against T. vaginalis.

Authors

  • Aysegul A Gokmen
    Department of Microbiology, Faculty of Medicine, İzmir Katip Çelebi University, İzmir, Turkey. aaksoygokmen@hotmail.com.
  • Hüseyin Can
    Molecular Biology Section, Department of Biology, Faculty of Science, Ege University, İzmir, Turkey. huseyin.can@ege.edu.tr.
  • Hüsniye Kayalar
    Department of Pharmacognosy, Faculty of Pharmacy, Ege University, İzmir, Turkey. husniye.kayalar@ege.edu.tr.
  • Bayram Pektaş
    Department of Microbiology, İzmir Atatürk Training and Research Hospital, Yeşilyurt, İzmir, Turkey. pektas2000@yahoo.com.
  • Selçuk Kaya
    Department of Microbiology, Faculty of Medicine, İzmir Katip Çelebi University, İzmir, Turkey. selcukkayadr@hotmail.com.

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