AIMC Topic: Antiprotozoal Agents
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Design and Synthesis of Magnolol Derivatives Using Integrated CNNs and Pharmacophore Approaches for Enhanced Parasiticidal Activity in Aquaculture.
Journal of agricultural and food chemistry
Apr 16, 2025
Aquaculture is a rapidly growing sector of global food production, playing a vital role in poverty alleviation, food security, and income generation. However, it faces substantial challenges, particularly due to infections caused by the protozoan , l...
Application of Machine Learning (ML) approach in discovery of novel drug targets against Leishmania: A computational based approach.
Computational biology and chemistry
Mar 12, 2025
Molecules with potent anti-leishmanial activity play a crucial role in identifying treatments for leishmaniasis and aiding in the design of novel drugs to combat the disease, ultimately protecting individuals and populations. Various methods have bee...
Approved drugs successfully repurposed against based on machine learning predictions.
Frontiers in cellular and infection microbiology
Sep 26, 2024
Drug repurposing is a promising approach towards the discovery of novel treatments against Neglected Tropical Diseases, such as Leishmaniases, presenting the advantage of reducing both costs and duration of the drug discovery process. In previous wor...
E-pharmacophore and deep learning based high throughput virtual screening for identification of CDPK1 inhibitors of Cryptosporidium parvum.
Computational biology and chemistry
Aug 13, 2024
Cryptosporidiosis, a prevalent gastrointestinal illness worldwide, is caused by the protozoan parasite Cryptosporidium parvum. Calcium-dependent protein kinase 1 (CpCDPK1), crucial for the parasite's life cycle, serves as a promising drug target due ...
Scoping Review of Deep Learning Techniques for Diagnosis, Drug Discovery, and Vaccine Development in Leishmaniasis.
Transboundary and emerging diseases
Jan 17, 2024
, a single-cell parasite prevalent in tropical and subtropical regions worldwide, can cause varying degrees of leishmaniasis, ranging from self-limiting skin lesions to potentially fatal visceral complications. As such, the parasite has been the subj...
Machine Learning Analysis of Essential Oils from Cuban Plants: Potential Activity against Protozoa Parasites.
Molecules (Basel, Switzerland)
Feb 17, 2022
Essential oils (EOs) are a mixture of chemical compounds with a long history of use in food, cosmetics, perfumes, agricultural and pharmaceuticals industries. The main object of this study was to find chemical patterns between 45 EOs and antiprotozoa...
Ensemble learning application to discover new trypanothione synthetase inhibitors.
Molecular diversity
Jul 15, 2021
Trypanosomatid-caused diseases are among the neglected infectious diseases with the highest disease burden, affecting about 27 million people worldwide and, in particular, socio-economically vulnerable populations. Trypanothione synthetase (TryS) is ...
In vitro anti-Trichomonas vaginalis activity of Haplophyllum myrtifolium.
Journal of infection in developing countries
Mar 31, 2019
INTRODUCTION: In the classic treatment of Trichomonas vaginalis infection, although metronidazole has been used since the 1960s, there has been an increase in MTZ-resistant T. vaginalis strains and failure in the treatment of trichomoniasis causes se...
Development of Predictive QSAR Models of 4-Thiazolidinones Antitrypanosomal Activity Using Modern Machine Learning Algorithms.
Molecular informatics
Nov 14, 2017
This paper presents novel QSAR models for the prediction of antitrypanosomal activity among thiazolidines and related heterocycles. The performance of four machine learning algorithms: Random Forest regression, Stochastic gradient boosting, Multivari...
ANTIPROTOZOAL ACTIVITY OF EXTRACTS OF (CELASTRACEAE).
African journal of traditional, complementary, and alternative medicines : AJTCAM
Jul 3, 2016
BACKGROUND: Chagas disease, amebiasis, giardiasis and trichomoniasis represent a serious health problem in Latin America. The drugs employed to treat these illnesses produce important side effects and resistant strains have appeared. The present stud...
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