The identification of gene signatures in patients with extranodal NK/T-cell lymphoma from a pair of twins.

Journal: BMC cancer
PMID: 34872521

Abstract

BACKGROUND: There is no unified treatment standard for patients with extranodal NK/T-cell lymphoma (ENKTL). Cancer neoantigens are the result of somatic mutations and cancer-specific. Increased number of somatic mutations are associated with anti-cancer effects. Screening out ENKTL-specific neoantigens on the surface of cancer cells relies on the understanding of ENKTL mutation patterns. Hence, it is imperative to identify ENKTL-specific genes for ENKTL diagnosis, the discovery of tumor-specific neoantigens and the development of novel therapeutic strategies. We investigated the gene signatures of ENKTL patients.

Authors

  • Yang Wang
    Department of General Surgery The First People's Hospital of Yunnan Province, The Affiliated Hospital of Kunming University of Science and Technology Kunming China.
  • Huaicheng Tan
    Laboratory of Aging Research and Cancer Drug Target, State Key Laboratory of Biotherapy, National Clinical Research Center for Geriatrics, West China Hospital, Sichuan University, No. 17, Block 3, Southern Renmin Road, Chengdu, Sichuan, 610041, PR China.
  • Ting Yu
    Ministry of Agriculture Key Lab of Molecular Biology of Crop Pathogens and Insect Pests, Key Laboratory of Biology of Crop Pathogens and Insects of Zhejiang Province, Institute of Insect Sciences, College of Agricultural and Biotechnology, Zhejiang University, Hangzhou, China.
  • Xuelei Ma
  • Xiaoxuan Chen
    State Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, 610041, China.
  • Fangqi Jing
    State Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, 610041, China.
  • Liqun Zou
    Department of Head and Neck Cancer, Cancer Center, West China Hospital, Sichuan University, Chengdu, China.
  • Huashan Shi
    Department of Biotherapy, Cancer Center, West China Hospital, Sichuan University, Chengdu, China. shihuashan@scu.edu.cn.

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