AIMC Topic: Twins
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Digital twins and artificial intelligence in metabolic disease research.
Trends in endocrinology and metabolism: TEM
May 13, 2024
Digital twin technology is emerging as a transformative paradigm for personalized medicine in the management of chronic conditions. In this article, we explore the concept and key characteristics of a digital twin and its applications in chronic non-...
The identification of gene signatures in patients with extranodal NK/T-cell lymphoma from a pair of twins.
BMC cancer
Dec 6, 2021
BACKGROUND: There is no unified treatment standard for patients with extranodal NK/T-cell lymphoma (ENKTL). Cancer neoantigens are the result of somatic mutations and cancer-specific. Increased number of somatic mutations are associated with anti-can...
MRI-visible dilated perivascular spaces in healthy young adults: A twin heritability study.
Human brain mapping
Sep 8, 2020
We investigated the narrow-sense heritability of MRI-visible dilated perivascular spaces (dPVS) in healthy young adult twins and nontwin siblings (138 monozygotic, 79 dizygotic twin pairs, and 133 nontwin sibling pairs; 28.7 ± 3.6 years) from the Hum...
Predicting mental health problems in adolescence using machine learning techniques.
PloS one
Apr 6, 2020
BACKGROUND: Predicting which children will go on to develop mental health symptoms as adolescents is critical for early intervention and preventing future, severe negative outcomes. Although many aspects of a child's life, personality, and symptoms h...
A modern approach to identifying and characterizing child asthma and wheeze phenotypes based on clinical data.
PloS one
Dec 30, 2019
'Asthma' is a complex disease that encapsulates a heterogeneous group of phenotypes and endotypes. Research to understand these phenotypes has previously been based on longitudinal wheeze patterns or hypothesis-driven observational criteria. The aim ...
Using person-specific neural networks to characterize heterogeneity in eating disorders: Illustrative links between emotional eating and ovarian hormones.
The International journal of eating disorders
Aug 21, 2018
OBJECTIVE: Emotional eating has been linked to ovarian hormone functioning, but no studies to-date have considered the role of brain function. This knowledge gap may stem from methodological challenges: Data are heterogeneous, violating assumptions o...
Development of the brain's structural network efficiency in early adolescence: A longitudinal DTI twin study.
Human brain mapping
Sep 14, 2015
The brain is a network and our intelligence depends in part on the efficiency of this network. The network of adolescents differs from that of adults suggesting developmental changes. However, whether the network changes over time at the individual l...
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