Strengths and caveats of identifying resistance genes from whole genome sequencing data.

Journal: Expert review of anti-infective therapy
Published Date: Dec 16, 2021

Abstract

INTRODUCTION: Antimicrobial resistance (AMR) continues to present major challenges to modern healthcare. Recent advances in whole-genome sequencing (WGS) have made the rapid molecular characterization of AMR a realistic possibility for diagnostic laboratories; yet major barriers to clinical implementation exist.

Authors

  • Brian M Forde
    University of Queensland, Faculty of Medicine, Uq Centre for Clinical Research, Royal Brisbane and Woman's Hospital, Herston, Australia.
  • David M P De Oliveira
    University of Queensland, Faculty of Science, School of Chemistry and Molecular Biosciences, St Lucia, Australia.
  • Caitlin Falconer
    University of Queensland, Faculty of Medicine, Uq Centre for Clinical Research, Royal Brisbane and Woman's Hospital, Herston, Australia.
  • Bianca Graves
    Herston Infectious Disease Institute, Royal Brisbane & Women's Hospital, Herston, Australia.
  • Patrick N A Harris
    University of Queensland, Faculty of Medicine, Uq Centre for Clinical Research, Royal Brisbane and Woman's Hospital, Herston, Australia.

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