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Drug Resistance, Bacterial

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Leveraging Graph Neural Networks for MIC Prediction in Antimicrobial Resistance Studies.

Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference
Antimicrobial resistance (AMR) poses a significant challenge in healthcare and public health, with organisms such as nontyphoidal Salmonella leading the way due to their escalating resistance to antimicrobial agents. This situation severely complicat...

Machine learning for predicting antimicrobial resistance in critical and high-priority pathogens: A systematic review considering antimicrobial susceptibility tests in real-world healthcare settings.

PloS one
BACKGROUND: Antimicrobial resistance (AMR) poses a worldwide health threat; quick and accurate identification of AMR enhances patient outcomes and reduces inappropriate antibiotic usage. The objective of this systematic review is to evaluate the effi...

Targeting Bacterial RNA Polymerase: Harnessing Simulations and Machine Learning to Design Inhibitors for Drug-Resistant Pathogens.

Biochemistry
The increase in antimicrobial resistance presents a major challenge in treating bacterial infections, underscoring the need for innovative drug discovery approaches and novel inhibitors. Bacterial RNA polymerase (RNAP) has emerged as a crucial target...

Machine learning detection of heteroresistance in Escherichia coli.

EBioMedicine
BACKGROUND: Heteroresistance (HR) is a significant type of antibiotic resistance observed for several bacterial species and antibiotic classes where a susceptible main population contains small subpopulations of resistant cells. Mathematical models, ...

Quantitative prediction of disinfectant tolerance in Listeria monocytogenes using whole genome sequencing and machine learning.

Scientific reports
Listeria monocytogenes is a potentially severe disease-causing bacteria mainly transmitted through food. This pathogen is of great concern for public health and the food industry in particular. Many countries have implemented thorough regulations, an...

Assessment for antibiotic resistance in : A practical and interpretable machine learning model based on genome-wide genetic variation.

Virulence
() antibiotic resistance poses a global health threat. Accurate identification of antibiotic resistant strains is essential for the control of infection. In the present study, our goal is to leverage the whole-genome data of to develop practical an...

ListPred: A predictive ML tool for virulence potential and disinfectant tolerance in Listeria monocytogenes.

Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases
Despite current surveillance and sanitation strategies, foodborne pathogens continue to threaten the food industry and public health. Whole genome sequencing (WGS) has reached an unprecedented resolution to analyse and compare pathogenic bacterial is...

Strategies in using artificial intelligence to combat antimicrobial resistance.

Recenti progressi in medicina
Infectious diseases caused by pathogens resistant to antimicrobial treatments, defined as antimicrobial resistance (AMR), are a serious global health crisis, considered among the main threats to global public health according to the World Health Orga...

DRAMMA: a multifaceted machine learning approach for novel antimicrobial resistance gene detection in metagenomic data.

Microbiome
BACKGROUND: Antibiotics are essential for medical procedures, food security, and public health. However, ill-advised usage leads to increased pathogen resistance to antimicrobial substances, posing a threat of fatal infections and limiting the benefi...

Barriers to the widespread adoption of diagnostic artificial intelligence for preventing antimicrobial resistance.

Scientific reports
Currently, antimicrobial resistance (AMR) poses a major public health challenge. The emergence of AMR, which significantly threatens public health, is primarily due to the overuse of antimicrobial agents. This study explored the possibility that the ...