A deep learning-based algorithm for tall cell detection in papillary thyroid carcinoma.

Journal: PloS one
Published Date: Aug 9, 2022

Abstract

INTRODUCTION: According to the World Health Organization, the tall cell variant (TCV) is an aggressive subtype of papillary thyroid carcinoma (PTC) comprising at least 30% epithelial cells two to three times as tall as they are wide. In practice, applying this definition is difficult causing substantial interobserver variability. We aimed to train a deep learning algorithm to detect and quantify the proportion of tall cells (TCs) in PTC.

Authors

  • Sebastian Stenman
  • Nina Linder
    Institute for Molecular Medicine Finland (FIMM), HiLIFE, University of Helsinki, Helsinki, Finland.
  • Mikael Lundin
    Institute for Molecular Medicine Finland, HILIFE, University of Helsinki, Helsinki, Finland.
  • Caj Haglund
    Research Programs Unit, Translational Cancer Biology, University of Helsinki, Helsinki, Finland.
  • Johanna Arola
  • Johan Lundin
    Institute for Molecular Medicine Finland (FIMM), HiLIFE, University of Helsinki, Helsinki, Finland.

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