Deep Learning-Assisted Repurposing of Plant Compounds for Treating Vascular Calcification: An In Silico Study with Experimental Validation.

Journal: Oxidative medicine and cellular longevity
Published Date: Jan 5, 2022

Abstract

BACKGROUND: Vascular calcification (VC) constitutes subclinical vascular burden and increases cardiovascular mortality. Effective therapeutics for VC remains to be procured. We aimed to use a deep learning-based strategy to screen and uncover plant compounds that potentially can be repurposed for managing VC.

Authors

  • Chia-Ter Chao
    Department of Medicine, National Taiwan University Hospital BeiHu Branch, College of Medicine, National Taiwan University, Taipei, Taiwan.
  • You-Tien Tsai
    Nephrology Division, Department of Internal Medicine, National Taiwan University College of Medicine, Taipei, Taiwan.
  • Wen-Ting Lee
    School of Big Data Management, Soochow University, Taipei, Taiwan.
  • Hsiang-Yuan Yeh
    School of Big Data Management, Soochow University, Taipei, Taiwan.
  • Chih-Kang Chiang
    Graduate Institute of Toxicology, National Taiwan University College of Medicine, Taipei, Taiwan.

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