Machine learning for emerging infectious disease field responses.

Journal: Scientific reports
Published Date:

Abstract

Emerging infectious diseases (EIDs), including the latest COVID-19 pandemic, have emerged and raised global public health crises in recent decades. Without existing protective immunity, an EID may spread rapidly and cause mass casualties in a very short time. Therefore, it is imperative to identify cases with risk of disease progression for the optimized allocation of medical resources in case medical facilities are overwhelmed with a flood of patients. This study has aimed to cope with this challenge from the aspect of preventive medicine by exploiting machine learning technologies. The study has been based on 83,227 hospital admissions with influenza-like illness and we analysed the risk effects of 19 comorbidities along with age and gender for severe illness or mortality risk. The experimental results revealed that the decision rules derived from the machine learning based prediction models can provide valuable guidelines for the healthcare policy makers to develop an effective vaccination strategy. Furthermore, in case the healthcare facilities are overwhelmed by patients with EID, which frequently occurred in the recent COVID-19 pandemic, the frontline physicians can incorporate the proposed prediction models to triage patients suffering minor symptoms without laboratory tests, which may become scarce during an EID disaster. In conclusion, our study has demonstrated an effective approach to exploit machine learning technologies to cope with the challenges faced during the outbreak of an EID.

Authors

  • Han-Yi Robert Chiu
    Department of Emergency Medicine, National Taiwan University Hospital and College of Medicine, National Taiwan University, No. 7 Chung Shan S. Road, Taipei, 100, Taiwan, ROC.
  • Chun-Kai Hwang
    Department of Computer Science and Information Engineering, National Taiwan University, Taipei, 106, Taiwan, ROC.
  • Shey-Ying Chen
    Department of Emergency Medicine, National Taiwan University Hospital and College of Medicine, National Taiwan University, No. 7 Chung Shan S. Road, Taipei, 100, Taiwan, ROC.
  • Fuh-Yuan Shih
    Department of Emergency Medicine, National Taiwan University Hospital and College of Medicine, National Taiwan University, No. 7 Chung Shan S. Road, Taipei, 100, Taiwan, ROC.
  • Hsieh-Cheng Han
    Research Center for Applied Sciences, Academia Sinica, Taipei, Taiwan, Republic of China.
  • Chwan-Chuen King
    Institute of Epidemiology and Preventive Medicine, College of Public Health, National Taiwan University, Taipei, Taiwan, Republic of China.
  • John Reuben Gilbert
    Department of Computer Science and Information Engineering, National Taiwan University, Taipei, 106, Taiwan, ROC.
  • Cheng-Chung Fang
    Department of Emergency Medicine, National Taiwan University Hospital and College of Medicine, National Taiwan University, No. 7 Chung Shan S. Road, Taipei, 100, Taiwan, ROC. conrad@ntu.edu.tw.
  • Yen-Jen Oyang
    Graduate Institute of Biomedical Electronics and Bioinformatics, National Taiwan University, Taipei, 10617, Taiwan.