Natural Language Processing-Assisted Literature Retrieval and Analysis for Combination Therapy in Cancer.

Journal: JCO clinical cancer informatics
Published Date: Jan 1, 2022

Abstract

PURPOSE: Despite advances in molecular therapeutics, few anticancer agents achieve durable responses. Rational combinations using two or more anticancer drugs have the potential to achieve a synergistic effect and overcome drug resistance, enhancing antitumor efficacy. A publicly accessible biomedical literature search engine dedicated to this domain will facilitate knowledge discovery and reduce manual search and review.

Authors

  • Jia Zeng
    Center for Computational Biomedicine, School of Biomedical Informatics, University of Texas Health Science Center at Houston, Houston, TX 77030, USA, Department of Public Health Science, Medical University of South Carolina, 135 Cannon Street, Suite 303, Charleston, SC 29425, USA and Department of Investigational Cancer Therapeutics, Institute for Personalized Cancer Therapy, UT-MD Anderson Cancer Center, 1400 Holcombe Blvd., FC8.3044, Houston, TX 77030, USA.
  • Christian X Cruz-Pico
    Department of Surgical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX.
  • Turçin Saridogan
    Department of Investigational Cancer Therapeutics, The University of Texas MD Anderson Cancer Center, Houston, TX.
  • Md Abu Shufean
    Sheikh Khalifa Bin Zayed Al Nahyan Institute for Personalized Cancer Therapy, The University of Texas MD Anderson Cancer Center, Houston, TX, U.S.A.
  • Michael Kahle
    Sheikh Khalifa Bin Zayed Al Nahyan Institute for Personalized Cancer Therapy, The University of Texas MD Anderson Cancer Center, Houston, TX.
  • Dong Yang
    College of Chemistry and Chemical Engineering, Shaanxi University of Science and Technology Xi'an 710021 China yangdong@sust.edu.cn.
  • Kenna Shaw
    Department of Genomic Medicine, MD Anderson Cancer Center, Houston, Texas, USA.
  • Funda Meric-Bernstam
    Center for Computational Biomedicine, School of Biomedical Informatics, University of Texas Health Science Center at Houston, Houston, TX 77030, USA, Department of Public Health Science, Medical University of South Carolina, 135 Cannon Street, Suite 303, Charleston, SC 29425, USA and Department of Investigational Cancer Therapeutics, Institute for Personalized Cancer Therapy, UT-MD Anderson Cancer Center, 1400 Holcombe Blvd., FC8.3044, Houston, TX 77030, USA.

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