Higher serum levels of fibroblast growth factor 21 in old patients with cachexia.

Journal: Nutrition (Burbank, Los Angeles County, Calif.)
PMID: 30933730

Abstract

OBJECTIVE: Fibroblast growth factor (FGF)21 is promptly induced by short fasting in animal models to regulate glucose and fat metabolism. Data on FGF21 in humans are inconsistent and FGF21 has not yet been investigated in old patients with cachexia, a complex syndrome characterized by inflammation and weight loss. The aim of this study was to explore the association of FGF21 with cachexia in old patients compared with their healthy counterparts.

Authors

  • Kristina Franz
    Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt Universität zu Berlin and Berlin Institute of Health, Research Group on Geriatrics, Working Group Nutrition and Body Composition, Berlin, Germany.
  • Mario Ost
    German Institute of Human Nutrition Potsdam - Rehbrücke, Department of Physiology and Energy Metabolism, Nuthetal, Germany.
  • Lindsey Otten
    Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt Universität zu Berlin and Berlin Institute of Health, Research Group on Geriatrics, Working Group Nutrition and Body Composition, Berlin, Germany.
  • Catrin Herpich
    German Institute of Human Nutrition Potsdam - Rehbrücke, Department of Nutrition and Gerontology, Nuthetal, Germany.
  • Verena Coleman
    German Institute of Human Nutrition Potsdam - Rehbrücke, Department of Physiology and Energy Metabolism, Nuthetal, Germany.
  • Anne-Sophie Endres
    Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt Universität zu Berlin and Berlin Institute of Health, Research Group on Geriatrics, Berlin, Germany; Protestant Geriatric Center Berlin, Berlin, Germany.
  • Susanne Klaus
    German Institute of Human Nutrition Potsdam - Rehbrücke, Department of Physiology and Energy Metabolism, Nuthetal, Germany; University of Potsdam, Institute of Nutritional Science, Nuthetal, Germany.
  • Ursula Müller-Werdan
    Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt Universität zu Berlin and Berlin Institute of Health, Research Group on Geriatrics, Berlin, Germany; Protestant Geriatric Center Berlin, Berlin, Germany.
  • Kristina Norman
    Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt Universität zu Berlin and Berlin Institute of Health, Research Group on Geriatrics, Working Group Nutrition and Body Composition, Berlin, Germany; German Institute of Human Nutrition Potsdam - Rehbrücke, Department of Nutrition and Gerontology, Nuthetal, Germany; University of Potsdam, Institute of Nutritional Science, Nuthetal, Germany. Electronic address: kristina.norman@dife.de.

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