Feature selection enhances peptide binding predictions for TCR-specific interactions.
Journal:
Frontiers in immunology
PMID:
39916960
Abstract
INTRODUCTION: T-cell receptors (TCRs) play a critical role in the immune response by recognizing specific ligand peptides presented by major histocompatibility complex (MHC) molecules. Accurate prediction of peptide binding to TCRs is essential for advancing immunotherapy, vaccine design, and understanding mechanisms of autoimmune disorders.