SPEQ: quality assessment of peptide tandem mass spectra with deep learning.

Journal: Bioinformatics (Oxford, England)
Published Date: Mar 4, 2022

Abstract

MOTIVATION: In proteomics, database search programs are routinely used for peptide identification from tandem mass spectrometry data. However, many low-quality spectra cannot be interpreted by any programs. Meanwhile, certain high-quality spectra may not be identified due to incompleteness of the database or failure of the software. Thus, spectrum quality (SPEQ) assessment tools are helpful programs that can eliminate poor-quality spectra before the database search and highlight the high-quality spectra that are not identified in the initial search. These spectra may be valuable candidates for further analyses.

Authors

  • Soroosh Gholamizoj
    David R. Cheriton School of Computer Science, University of Waterloo, Waterloo, ON N2L 3G1, Canada.
  • Bin Ma
    Key Laboratory of Beijing for Water Quality Science and Water Environment Recovery Engineering, Engineering Research Center of Beijing, Beijing University of Technology, Beijing 10024, China.

Keywords

External Resources

Popular Topics
Recent Journals