The Essentials of Multiomics.

Journal: The oncologist
Published Date: Apr 5, 2022

Abstract

Within the last decade, the science of molecular testing has evolved from single gene and single protein analysis to broad molecular profiling as a standard of care, quickly transitioning from research to practice. Terms such as genomics, transcriptomics, proteomics, circulating omics, and artificial intelligence are now commonplace, and this rapid evolution has left us with a significant knowledge gap within the medical community. In this paper, we attempt to bridge that gap and prepare the physician in oncology for multiomics, a group of technologies that have gone from looming on the horizon to become a clinical reality. The era of multiomics is here, and we must prepare ourselves for this exciting new age of cancer medicine.

Authors

  • John L Marshall
    Lombardi Comprehensive Cancer Center, Georgetown University Medical Center, Washington, DC, USA.
  • Beth N Peshkin
    Georgetown University, Lombardi Comprehensive Cancer Center, Washington, DC, USA.
  • Takayuki Yoshino
    National Cancer Center Hospital East, Chiba, Japan.
  • Jakob Vowinckel
    Biognosys AG, Schlieren, Switzerland.
  • Håvard E Danielsen
    Institute for Cancer Genetics and Informatics, Oslo University Hospital, Oslo, Norway; Department of Informatics, University of Oslo, Oslo, Norway; Nuffield Division of Clinical Laboratory Sciences, University of Oxford, Oxford, UK. Electronic address: hdaniels@labmed.uio.no.
  • Gerry Melino
    Department of Experimental Medicine, TOR, University of Rome Tor Vergata, Rome, Italy.
  • Ioannis Tsamardinos
    2 Department of Computer Science, University of Huddersfield, UK.
  • Christian Haudenschild
  • David J Kerr
    Nuffield Division of Clinical Laboratory Sciences, University of Oxford, Oxford, UK.
  • Carlos Sampaio
    Clinica AMO, Rio Vermelho, Salvador-BA, Brasil.
  • Sun Young Rha
    Yonsei Cancer Center, Yonsei University College of Medicine, Seodaemun-Ku, Seoul, Korea.
  • Kevin T FitzGerald
    Department of Medical Humanities in the School of Medicine, Creighton University, Omaha, NE, USA.
  • Eric C Holland
    Division of Human Biology, Fred Hutchinson Cancer Research Center, Seattle, WA, USA.
  • David Gallagher
    St. James's Hospital/Trinity College Dublin, St. Raphael's House, Dublin, Ireland.
  • Jesus Garcia-Foncillas
    Cancer Institute, Fundacion Jimenez Diaz University Hospital, Autonomous University, Madrid, Spain.
  • Hartmut Juhl
    Indivumed GmbH, Hamburg, Germany.

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