Classification of antiseizure drugs in cultured neuronal networks using multielectrode arrays and unsupervised learning.

Journal: Epilepsia
PMID: 35460272

Abstract

OBJECTIVE: Antiseizure drugs (ASDs) modulate synaptic and ion channel function to prevent abnormal hypersynchronous or excitatory activity arising in neuronal networks, but the relationship between ASDs with respect to their impact on network activity is poorly defined. In this study, we first investigated whether different ASD classes exert differential impact upon network activity, and we then sought to classify ASDs according to their impact on network activity.

Authors

  • Alexander Bryson
    Ion Channels and Diseases Group, Florey Institute of Neuroscience and Mental Health, Parkville, Victoria, Australia.
  • Dulini Mendis
    Seer Medical, Melbourne, Victoria, Australia.
  • Emma Morrisroe
    Ion Channels and Diseases Group, Florey Institute of Neuroscience and Mental Health, Parkville, Victoria, Australia.
  • Christopher A Reid
    Ion Channels and Diseases Group, Florey Institute of Neuroscience and Mental Health, Parkville, Victoria, Australia.
  • Saman Halgamuge
  • Steven Petrou
    Ion Channels and Diseases Group, Florey Institute of Neuroscience and Mental Health, Parkville, Victoria, Australia.

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