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Receptors, GABA

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The Variability of Translocator Protein Signal in Brain and Blood of Genotyped Healthy Humans Using In Vivo I-CLINDE SPECT Imaging: A Test-Retest Study.

Journal of nuclear medicine : official publication, Society of Nuclear Medicine 28572290
I-CLINDE is a radiotracer developed for SPECT and targets the 18-kDa translocator protein (TSPO). TSPO is upregulated in glial cells and used as a measure of neuroinflammation in a variety of central nervous system diseases. The aim of this study was...
Adult Aged Aged, 80 and over Biomarkers Brain Bridged Bicyclo Compounds, Heterocyclic Female Genotype Humans Male Middle Aged Molecular Imaging Radiopharmaceuticals Receptors, GABA Reference Values Reproducibility of Results Sensitivity and Specificity Tissue Distribution Tomography, Emission-Computed, Single-Photon
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Mechanism-Based and Input-Output Modeling of the Key Neuronal Connections and Signal Transformations in the CA3-CA1 Regions of the Hippocampus.

Neural computation 29064783
This letter examines the results of input-output (nonparametric) modeling based on the analysis of data generated by a mechanism-based (parametric) model of CA3-CA1 neuronal connections in the hippocampus. The motivation is to obtain biological insig...
Action Potentials Animals CA1 Region, Hippocampal CA3 Region, Hippocampal Humans Models, Neurological Neural Inhibition Neural Networks, Computer Neurons Nonlinear Dynamics Receptors, GABA Receptors, N-Methyl-D-Aspartate Synapses
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Classification of antiseizure drugs in cultured neuronal networks using multielectrode arrays and unsupervised learning.

Epilepsia 35460272
OBJECTIVE: Antiseizure drugs (ASDs) modulate synaptic and ion channel function to prevent abnormal hypersynchronous or excitatory activity arising in neuronal networks, but the relationship between ASDs with respect to their impact on network activit...
gamma-Aminobutyric Acid Neurons Receptors, GABA Sodium Channel Blockers Unsupervised Machine Learning
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Machine learning-based approach reveals essential features for simplified TSPO PET quantification in ischemic stroke patients.

Zeitschrift fur medizinische Physik 36682921
INTRODUCTION: Neuroinflammation evaluation after acute ischemic stroke is a promising option for selecting an appropriate post-stroke treatment strategy. To assess neuroinflammation in vivo, translocator protein PET (TSPO PET) can be used. However, t...
Aged Aged, 80 and over Carbazoles Female Humans Ischemic Stroke Machine Learning Magnetic Resonance Imaging Male Middle Aged Positron-Emission Tomography Radiopharmaceuticals Receptors, GABA
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Physically informed deep neural networks for metabolite-corrected plasma input function estimation in dynamic PET imaging.

Computer methods and programs in biomedicine 39180914
INTRODUCTION: We propose a novel approach for the non-invasive quantification of dynamic PET imaging data, focusing on the arterial input function (AIF) without the need for invasive arterial cannulation.
Adult Algorithms Brain Female Humans Image Processing, Computer-Assisted Male Middle Aged Neural Networks, Computer Positron-Emission Tomography Pyridines Receptors, GABA Reproducibility of Results
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Proteomic Learning of Gamma-Aminobutyric Acid (GABA) Receptor-Mediated Anesthesia.

Journal of chemical information and modeling 40094320
Anesthetics are crucial in surgical procedures and therapeutic interventions, but they come with side effects and varying levels of effectiveness, calling for novel anesthetic agents that offer more precise and controllable effects. Targeting Gamma-a...
Anesthetics Humans Machine Learning Protein Interaction Maps Proteomics Receptors, GABA
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