AIMC Topic: Receptors, GABA

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Proteomic Learning of Gamma-Aminobutyric Acid (GABA) Receptor-Mediated Anesthesia.

Journal of chemical information and modeling Mar 17, 2025
Anesthetics are crucial in surgical procedures and therapeutic interventions, but they come with side effects and varying levels of effectiveness, calling for novel anesthetic agents that offer more precise and controllable effects. Targeting Gamma-a...
Humans Proteomics Receptors, GABA Anesthetics Machine Learning Protein Interaction Maps
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Physically informed deep neural networks for metabolite-corrected plasma input function estimation in dynamic PET imaging.

Computer methods and programs in biomedicine Aug 20, 2024
INTRODUCTION: We propose a novel approach for the non-invasive quantification of dynamic PET imaging data, focusing on the arterial input function (AIF) without the need for invasive arterial cannulation.
Humans Receptors, GABA Pyridines Positron-Emission Tomography Reproducibility of Results Brain Adult Neural Networks, Computer Female Algorithms Male Middle Aged Image Processing, Computer-Assisted
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Machine learning-based approach reveals essential features for simplified TSPO PET quantification in ischemic stroke patients.

Zeitschrift fur medizinische Physik Jan 20, 2023
INTRODUCTION: Neuroinflammation evaluation after acute ischemic stroke is a promising option for selecting an appropriate post-stroke treatment strategy. To assess neuroinflammation in vivo, translocator protein PET (TSPO PET) can be used. However, t...
Magnetic Resonance Imaging Ischemic Stroke Male Middle Aged Receptors, GABA Carbazoles Radiopharmaceuticals Positron-Emission Tomography Machine Learning Female Aged Aged, 80 and over Humans
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Classification of antiseizure drugs in cultured neuronal networks using multielectrode arrays and unsupervised learning.

Epilepsia May 10, 2022
OBJECTIVE: Antiseizure drugs (ASDs) modulate synaptic and ion channel function to prevent abnormal hypersynchronous or excitatory activity arising in neuronal networks, but the relationship between ASDs with respect to their impact on network activit...
Sodium Channel Blockers gamma-Aminobutyric Acid Receptors, GABA Unsupervised Machine Learning Neurons
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Mechanism-Based and Input-Output Modeling of the Key Neuronal Connections and Signal Transformations in the CA3-CA1 Regions of the Hippocampus.

Neural computation Oct 24, 2017
This letter examines the results of input-output (nonparametric) modeling based on the analysis of data generated by a mechanism-based (parametric) model of CA3-CA1 neuronal connections in the hippocampus. The motivation is to obtain biological insig...
Animals Models, Neurological Action Potentials Neurons Humans Neural Networks, Computer CA3 Region, Hippocampal Receptors, GABA Receptors, N-Methyl-D-Aspartate Nonlinear Dynamics CA1 Region, Hippocampal Synapses Neural Inhibition
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The Variability of Translocator Protein Signal in Brain and Blood of Genotyped Healthy Humans Using In Vivo I-CLINDE SPECT Imaging: A Test-Retest Study.

Journal of nuclear medicine : official publication, Society of Nuclear Medicine Nov 10, 2016
I-CLINDE is a radiotracer developed for SPECT and targets the 18-kDa translocator protein (TSPO). TSPO is upregulated in glial cells and used as a measure of neuroinflammation in a variety of central nervous system diseases. The aim of this study was...
Tomography, Emission-Computed, Single-Photon Receptors, GABA Middle Aged Genotype Sensitivity and Specificity Bridged Bicyclo Compounds, Heterocyclic Molecular Imaging Reproducibility of Results Brain Male Radiopharmaceuticals Humans Tissue Distribution Aged Aged, 80 and over Female Reference Values Biomarkers Adult
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