Deep learning based low-activity PET reconstruction of [C]PiB and [F]FE-PE2I in neurodegenerative disorders.

Journal: NeuroImage
Published Date: Oct 1, 2022

Abstract

PURPOSE: Positron Emission Tomography (PET) can support a diagnosis of neurodegenerative disorder by identifying disease-specific pathologies. Our aim was to investigate the feasibility of using activity reduction in clinical [F]FE-PE2I and [C]PiB PET/CT scans, simulating low injected activity or scanning time reduction, in combination with AI-assisted denoising.

Authors

  • Raphaël Sura Daveau
    Department of Clinical Physiology and Nuclear Medicine, Rigshospitalet, University of Copenhagen, Denmark.
  • Ian Law
    Department of Clinical Physiology, Nuclear Medicine and PET, Rigshospitalet, Copenhagen, Denmark.
  • Otto Mølby Henriksen
    Department of Clinical Physiology, Nuclear Medicine & PET, Rigshospitalet, University of Copenhagen, Denmark.
  • Steen Gregers Hasselbalch
    Danish Dementia Research Centre, Rigshospitalet, University of Copenhagen, Denmark.
  • Ulrik Bjørn Andersen
    Department of Clinical Physiology and Nuclear Medicine, Rigshospitalet, University of Copenhagen, Denmark.
  • Lasse Anderberg
    Department of Clinical Physiology and Nuclear Medicine, Rigshospitalet, University of Copenhagen, Denmark.
  • Liselotte Højgaard
    Department of Clinical Physiology, Nuclear Medicine and PET, Rigshospitalet, Copenhagen, Denmark.
  • Flemming Littrup Andersen
    Department of Clinical Physiology, Nuclear Medicine and PET, Rigshospitalet, Copenhagen, Denmark.
  • Claes Nøhr Ladefoged
    Department of Clinical Physiology, Nuclear Medicine and PET, Rigshospitalet, Copenhagen, Denmark.

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