Microarchitectural Changes of Cardiovascular Calcification in Response to In Vivo Interventions Using Deep-Learning Segmentation and Computed Tomography Radiomics.

Journal: Arteriosclerosis, thrombosis, and vascular biology
Published Date: Jun 16, 2022

Abstract

BACKGROUND: Coronary calcification associates closely with cardiovascular risk, but its progress is accelerated in response to some interventions widely used to reduce risk. This paradox suggests that qualitative, not just quantitative, changes in calcification may affect plaque stability. To determine if the microarchitecture of calcification varies with aging, Western diet, statin therapy, and high intensity, progressive exercise, we assessed changes in a priori selected computed tomography radiomic features (intensity, size, shape, and texture).

Authors

  • Nikhil Rajesh Patel
    Departments of Medicine (N.R.P., K.S., S.P., M.L., L.L.D., Y.T.), University of California, Los Angeles.
  • Kulveer Setya
    Departments of Medicine (N.R.P., K.S., S.P., M.L., L.L.D., Y.T.), University of California, Los Angeles.
  • Stuti Pradhan
    Departments of Medicine (N.R.P., K.S., S.P., M.L., L.L.D., Y.T.), University of California, Los Angeles.
  • Mimi Lu
    Departments of Medicine (N.R.P., K.S., S.P., M.L., L.L.D., Y.T.), University of California, Los Angeles.
  • Linda L Demer
    Departments of Medicine (N.R.P., K.S., S.P., M.L., L.L.D., Y.T.), University of California, Los Angeles.
  • Yin Tintut
    Departments of Medicine (N.R.P., K.S., S.P., M.L., L.L.D., Y.T.), University of California, Los Angeles.

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