Leveraging Human Genetics to Guide Cancer Drug Development.

Journal: JCO clinical cancer informatics
Published Date: Dec 1, 2018

Abstract

PURPOSE: The high attrition rate of cancer drug development programs is a barrier to realizing the promise of precision oncology. We have examined whether the genetic insights from genome-wide association studies of cancer can guide drug development and repurposing in oncology.

Authors

  • Ben Kinnersley
    All authors: The Institute of Cancer Research, London, United Kingdom.
  • Amit Sud
    All authors: The Institute of Cancer Research, London, United Kingdom.
  • Elizabeth A Coker
    All authors: The Institute of Cancer Research, London, United Kingdom.
  • Joseph E Tym
    All authors: The Institute of Cancer Research, London, United Kingdom.
  • Patrizio Di Micco
    All authors: The Institute of Cancer Research, London, United Kingdom.
  • Bissan Al-Lazikani
    All authors: The Institute of Cancer Research, London, United Kingdom.
  • Richard S Houlston
    All authors: The Institute of Cancer Research, London, United Kingdom.

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