Deep learning-based 4D-synthetic CTs from sparse-view CBCTs for dose calculations in adaptive proton therapy.

Journal: Medical physics
Published Date:

Abstract

BACKGROUND: Time-resolved 4D cone beam-computed tomography (4D-CBCT) allows a daily assessment of patient anatomy and respiratory motion. However, 4D-CBCTs suffer from imaging artifacts that affect the CT number accuracy and prevent accurate proton dose calculations. Deep learning can be used to correct CT numbers and generate synthetic CTs (sCTs) that can enable CBCT-based proton dose calculations.

Authors

  • Adrian Thummerer
    Department of Radiation Oncology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.
  • Carmen Seller Oria
    Department of Radiation Oncology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.
  • Paolo Zaffino
    Department of Experimental and Clinical Medicine, Magna Graecia University of Catanzaro, 88100, Catanzaro, Italy.
  • Sabine Visser
    Department, of Radiation Oncology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.
  • Arturs Meijers
  • Gabriel Guterres Marmitt
    Department of Radiation Oncology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.
  • Robin Wijsman
    Department of Radiation Oncology, Radboud University Medical Center, Nijmegen, The Netherlands.
  • Joao Seco
    Biomedical Physics in Radiation Oncology, DKFZ-Deutsches Krebsforschungszentrum, Heidelberg, Germany; Department of Physics and Astronomy, Heidelberg University, Germany. Electronic address: j.seco@dkfz.de.
  • Johannes Albertus Langendijk
    Department of Radiation Oncology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.
  • Antje Christin Knopf
    Department, of Radiation Oncology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.
  • Maria Francesca Spadea
    Department of Experimental and Clinical Medicine, Magna Graecia University of Catanzaro, Catanzaro, Italy.
  • Stefan Both
    Department of Radiation Oncology, University of Groningen, University Medical Center Groningen, The Netherlands.