Proton therapy treatment planning currently needs to account for relatively large range uncertainty margins primarily due to the semi-empirical calibration of the treatment planning x-ray computed tomography (CT) to proton stopping power relative to ...
Rapid and accurate quantitative assessment of muscle tissue characteristics is valuable for the diagnosis and monitoring of neuromuscular diseases (NMDs). Quantitative magnetic resonance imaging (MRI) enables non-invasive assessment of muscle patholo...
Metabolic dysfunction-associated steatotic liver disease (MASLD) is the most common cause of chronic liver disease worldwide, affecting over 30% of the global general population. Its progressive nature and association with other chronic diseases make...
INTRODUCTION: Enhancing paediatric asthma diagnosis is crucial. Molecular analysis of exhaled breath is a rapidly evolving field aimed at harnessing established and innovative technologies for clinical applications. This study evaluates the feasibili...
PURPOSE: The aim of this study was to develop a saturation transfer MR fingerprinting (ST-MRF) technique using a biophysics model-driven deep learning approach.
Physica medica : PM : an international journal devoted to the applications of physics to medicine and biology : official journal of the Italian Association of Biomedical Physics (AIFB)
Mar 20, 2025
PURPOSE: This study aims to develop a comprehensive simulation framework to connect radiation effects from the microscopic to the nanoscopic scale.
SAR and QSAR in environmental research
Nov 8, 2024
BACE1 has been regarded as an essential drug design target for treating Alzheimer's disease (AD). Multiple independent Gaussian accelerated molecular dynamics simulations (GaMD), deep learning (DL), and molecular mechanics general Born surface area (...
Amide proton transfer (APT) imaging, a technique sensitive to tissue pH, holds promise in the diagnosis of ischemic stroke. Achieving accurate and rapid APT imaging is crucial for this application. However, conventional APT quantification methods eit...
Cancer radiotherapie : journal de la Societe francaise de radiotherapie oncologique
Sep 21, 2024
PURPOSE: X-ray and proton irradiation have been reported to induce distinct modifications in cytokine expression in vitro and in vivo, suggesting a dissimilar inflammatory response between X-rays and protons. We aimed to investigate the differences i...
Rare tautomeric forms of nucleobases can lead to Watson-Crick-like (WC-like) mispairs in DNA, but the process of proton transfer is fast and difficult to detect experimentally. NMR studies show evidence for the existence of short-time WC-like guanine...
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