AsthmaKGxE: An asthma-environment interaction knowledge graph leveraging public databases and scientific literature.
Journal:
Computers in biology and medicine
PMID:
35963184
Abstract
MOTIVATION: Asthma is a complex heterogeneous disease resulting from intricate interactions between genetic and non-genetic factors related to environmental and psychosocial aspects. Discovery of such interactions can provide insights into the pathophysiology and etiology of asthma. In this paper, we propose an asthma knowledge graph (KG) built using a hybrid methodology for graph-based modeling of asthma complexity with a focus on environmental interactions. Using a heterogeneous set of public sources, we construct a genetic and pharmacogenetic asthma knowledge graph. The construction of this KG allowed us to shed more light on the lack of curated resources focused on environmental influences related to asthma. To remedy the lack of environmental data in our KG, we exploit the biomedical literature using state-of-the-art natural language processing and construct the first Asthma-Environment interaction catalog incorporating a continuously updated ensemble of environmental, psychological, nutritional and socio-economic influences. The catalog's most substantiated results are then integrated into the KG.