AIMC Topic: Asthma

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A baseline study of interpretable machine learning using GC-MS breath VOCs for classifying asthma, bronchiectasis, and COPD.

Scientific reports
Accurate differentiation among asthma, bronchiectasis, and chronic obstructive pulmonary disease (COPD) remains a critical challenge due to overlapping clinical symptoms and limitations of conventional diagnostic tools. This study establishes a trans...

Machine learning models incorporating genotype and ancestry improve severe asthma risk prediction.

Scientific reports
This study proposes a novel machine learning (ML)-based stacking technique that integrates Single Nucleotide Polymorphisms (SNPs) and inferred local ancestry (LA) to improve predictive accuracy in clinical outcomes. Asthma, particularly severe asthma...

Predicting the risk of asthma development in youth using machine learning models.

PloS one
Asthma is a chronic respiratory disease characterized by wheezing and difficulty breathing, which disproportionally affects 4.7 million children in the U.S. Currently, there is a lack of asthma predictive models for youth with good performance. This ...

E-RespiNet: An LLM-ELECTRA driven triple-stream CNN with feature fusion for asthma classification.

PloS one
Respiratory disease diagnosis remains challenging in resource-constrained settings, where limited specialist expertise contributes to diagnostic uncertainties affecting over 300 million people worldwide. This study presents E-RespiNet, a novel multi-...

Factors associated with allergic diseases in Chinese children aged 6-14 years.

BMC public health
BACKGROUND AND OBJECTIVES: We aimed to identify and optimize contributing factors associated with allergic diseases by machine/deep learning algorithms among school-age children aged 6-14 years.

Development of an explainable machine learning asthma prediction model using serum brominated flame retardants in a national population.

Clinical and experimental medicine
We aimed to explore the association of serum brominated flame retardant (BFR) metabolites and mixture profiles with asthma risk among US adults. Data were sourced from the National Health and Nutrition Examination Survey (NHANES), 1999-2023. Four mac...

Identification of clinically meaningful, overlapping obstructive respiratory disease subtypes via data-driven approaches in a primary care population.

BMC pulmonary medicine
BACKGROUND: Obstructive respiratory conditions, including asthma, bronchiectasis, and chronic obstructive pulmonary disease (COPD), are increasingly recognised as heterogeneous syndromes with significant overlap. Multiple disease pathways contribute ...

Linarin protects against asthma-induced airway epithelial ferroptosis and inflammation via ALDH2 regulation.

Phytomedicine : international journal of phytotherapy and phytopharmacology
BACKGROUND: Asthma, a complex disease characterized by airway epithelial dysfunction and chronic inflammation, poses ongoing therapeutic challenges.

Machine learning reveals limited predictive value of clinical factors for asthma exacerbations.

Scientific reports
While predictors of asthma exacerbation risk are generally well established, predictors of exacerbation severity remain largely undefined. Identifying robust clinical predictors of exacerbation severity is essential to support tailored management str...

Association between geriatric nutritional risk index (GNRI) and asthma in elderly individuals aged 60 and above: a cross-sectional study of the NHANES 2005-2018.

BMC pulmonary medicine
OBJECTIVE: The geriatric nutritional risk index (GNRI) is a promising tool for predicting nutrition-related complications in older adults. This study aimed to explore the association between GNRI and asthma in individuals aged 60 and above.