Probiotic and selenium co-supplementation, and the effects on clinical, metabolic and genetic status in Alzheimer's disease: A randomized, double-blind, controlled trial.

Journal: Clinical nutrition (Edinburgh, Scotland)
PMID: 30642737

Abstract

BACKGROUND AND AIMS: Combined probiotic and selenium supplementation may improve Alzheimer's disease (AD) by correcting metabolic abnormalities, and attenuating inflammation and oxidative stress. This study aimed to determine the effects of probiotic and selenium co-supplementation on cognitive function and metabolic status among patients with AD.

Authors

  • Omid Reza Tamtaji
    Physiology Research Center, Kashan University of Medical Sciences, Kashan, Iran.
  • Reza Heidari-Soureshjani
    Student Research Committee, Shahrekord University of Medical Sciences, Shahrekord, Iran.
  • Naghmeh Mirhosseini
    School of Public Health, University of Saskatchewan, Saskatoon, SK, Canada.
  • Ebrahim Kouchaki
    Physiology Research Center, Kashan University of Medical Sciences, Kashan, Iran; Department of Neurology, School of Medicine, Kashan University of Medical Sciences, Kashan, Iran.
  • Fereshteh Bahmani
    Research Center for Biochemistry and Nutrition in Metabolic Diseases, Kashan University of Medical Sciences, Kashan, Iran.
  • Esmat Aghadavod
    Research Center for Biochemistry and Nutrition in Metabolic Diseases, Kashan University of Medical Sciences, Kashan, Iran.
  • Maryam Tajabadi-Ebrahimi
    Faculty Member of Science Department, Science Faculty, Islamic Azad University, Tehran Central Branch, Tehran, Iran.
  • Zatollah Asemi
    Research Center for Biochemistry and Nutrition in Metabolic Diseases, Kashan University of Medical Sciences, Kashan, Iran. Electronic address: asemi_r@yahoo.com.

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