Identifying acute ischemic stroke patients within the thrombolytic treatment window using deep learning.

Journal: Journal of neuroimaging : official journal of the American Society of Neuroimaging
PMID: 36068184

Abstract

BACKGROUND AND PURPOSE: Treatment of acute ischemic stroke is heavily contingent upon time, as there is a strong relationship between time clock and tissue progression. Work has established imaging biomarker assessments as surrogates for time since stroke (TSS), namely, by comparing signal mismatch between diffusion-weighted imaging (DWI) and fluid-attenuated inversion recovery (FLAIR) imaging. Our goal was to develop an automatic technique for determining TSS from imaging that does not require subspecialist radiology expertise.

Authors

  • Jennifer S Polson
    Computational Diagnostics Lab, University of California, Los Angeles, CA 90024, USA; Department of Bioengineering, University of California, Los Angeles, CA 90024, USA.
  • Haoyue Zhang
    Department of Bioengineering, University of California, Los Angeles, Los Angeles, CA, USA.
  • Kambiz Nael
    Department of Radiology, University of California, Los Angeles, Los Angeles, CA, USA.
  • Noriko Salamon
    Department of Radiology, University of California, Los Angeles, Los Angeles, CA, USA.
  • Bryan Y Yoo
    Department of Radiology, University of California, Los Angeles, Los Angeles, California, USA.
  • Suzie El-Saden
    Medical Imaging Informatics; University of California, Los Angeles, CA.
  • Sidney Starkman
    Departments of Emergency Medicine and Neurology, University of California, Los Angeles, Los Angeles, California, USA.
  • Namkug Kim
    Department of Radiology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea.
  • Dong-Wha Kang
    Department of Neurology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, South Korea. (E.-J.L., H.-B.L., S.U.K., J.S.K., D.-W.K.).
  • William F Speier
    Computational Diagnostics Lab, University of California, Los Angeles, Los Angeles, California, USA.
  • Corey W Arnold
    Department of Bioengineering; University of California, Los Angeles, CA.

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