VGG-TSwinformer: Transformer-based deep learning model for early Alzheimer's disease prediction.
Journal:
Computer methods and programs in biomedicine
Published Date:
Nov 30, 2022
Abstract
BACKGROUND AND OBJECTIVE: Mild cognitive impairment (MCI) is a transitional state between normal aging and Alzheimer's disease (AD), and accurately predicting the progression trend of MCI is critical to the early prevention and treatment of AD. Brain structural magnetic resonance imaging (sMRI), as one of the most important biomarkers for the diagnosis of AD, has been applied in various deep learning models. However, due to the inherent disadvantage of deep learning in dealing with longitudinal medical image data, few applications of deep learning for longitudinal analysis of MCI, and the majority of existing deep learning algorithms for MCI progress prediction rely on the analysis of the sMRI images collected at a single time-point, ignoring the progressive nature of the disorder.