Transfer learning for genotype-phenotype prediction using deep learning models.

Journal: BMC bioinformatics
Published Date:

Abstract

BACKGROUND: For some understudied populations, genotype data is minimal for genotype-phenotype prediction. However, we can use the data of some other large populations to learn about the disease-causing SNPs and use that knowledge for the genotype-phenotype prediction of small populations. This manuscript illustrated that transfer learning is applicable for genotype data and genotype-phenotype prediction.

Authors

  • Muhammad Muneeb
    Department of Electrical Engineering and Computer Science, Center for Biotechnology Khalifa University, Khalifa University of Science and Technology, Abu Dhabi, United Arab Emirates.
  • Samuel Feng
    Department of Science and Engineering, Sorbonne University Abu Dhabi, PO Box 38044, Abu Dhabi, United Arab Emirates.
  • Andreas Henschel
    Department of Electrical Engineering and Computer Science, Center for Biotechnology Khalifa University, Khalifa University of Science and Technology, Abu Dhabi, United Arab Emirates. andreas.henschel@ku.ac.ae.