Development and validation of a deep learning algorithm based on fundus photographs for estimating the CAIDE dementia risk score.

Journal: Age and ageing
Published Date:

Abstract

BACKGROUND: the Cardiovascular Risk Factors, Aging, and Incidence of Dementia (CAIDE) dementia risk score is a recognised tool for dementia risk stratification. However, its application is limited due to the requirements for multidimensional information and fasting blood draw. Consequently, an effective and non-invasive tool for screening individuals with high dementia risk in large population-based settings is urgently needed.

Authors

  • Rong Hua
    Division of Esophageal Surgery, Department of Thoracic Surgery, Shanghai Chest Hospital, Shanghai Jiao Tong University, Shanghai, China.
  • Jianhao Xiong
    Beijing Tulip Partners Technology Co., Ltd, Beijing, China.
  • Gail Li
    Departments of Psychiatry and Behavioral Sciences, University of Washington, Seattle, WA, USA.
  • Yidan Zhu
    Peking University Clinical Research Institute, Peking University First Hospital, Beijing 100191, China; PUCRI Heart and Vascular Health Research Center at Peking University Shougang Hospital, Beijing 100191, China; Key Laboratory of Molecular Cardiovascular Sciences (Peking University), Ministry of Education, Beijing 100191, China.
  • Zongyuan Ge
    AIM for Health Lab, Faculty of IT, Monash University, Clayton, Victoria, Australia; Monash-Airdoc Research Lab, Faculty of IT, Monash University, Clayton, Victoria, Australia.
  • Yanjun Ma
    Peking University Clinical Research Institute, Peking University First Hospital, Beijing 100191, China; PUCRI Heart and Vascular Health Research Center at Peking University Shougang Hospital, Beijing 100191, China; Key Laboratory of Molecular Cardiovascular Sciences (Peking University), Ministry of Education, Beijing 100191, China.
  • Meng Fu
    Beijing Airdoc Technology Co., Ltd., Beijing 100081, China.
  • Chenglong Li
    Beijing Advanced Innovation Center for Food Nutrition and Human Health, College of Veterinary Medicine, China Agricultural University, Beijing Key Laboratory of Detection Technology for Animal-Derived Food Safety, Beijing Laboratory for Food Quality and Safety, Beijing, 100193, People's Republic of China.
  • Bin Wang
    State Key Laboratory of Soil Erosion and Dryland Farming on the Loess Plateau, Northwest A&F University, Yangling 712100, China; New South Wales Department of Primary Industries, Wagga Wagga Agricultural Institute, Wagga Wagga 2650, Australia. Electronic address: bin.a.wang@dpi.nsw.gov.au.
  • Li Dong
    Department of Cardiovascular Surgery, West China Hospital, Sichuan University, Chengdu, China. donglikn199@163.com.
  • Xin Zhao
    Florida International University.
  • Zhiqiang Ma
    Key Laboratory of Intelligent Information Processing of Jilin Universities, Northeast Normal University, Changchun 130117, China. Electronic address: zhiqiang.ma967@gmail.com.
  • Jili Chen
    Department of Ophthalmology, Shibei Hospital, Shanghai, China.
  • Xinxiao Gao
    Beijing Anzhen Hospital, Capital Medical University, Beijing 100029, China.
  • Chao He
    Department of Plant Protection, Institute of Vegetables and Flowers, Chinese Academy of Agricultural Sciences, Beijing 100081, PR China.
  • Zhaohui Wang
    Department of Plastic Surgery, Second Affiliated Hospital of Nanchang University, Nanchang Jiangxi, 330006, P.R.China.
  • Wenbin Wei
    Clinical Center for Eye Tumors, Capital Medical University, Beijing, 100730, China; Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, No. 1 Dongjiaominxiang Stree, Dongcheng District, Beijing, 100730, China; Beijing Key Laboratory of Intraocular Tumor Diagnosis and Treatment, Beijing 100730, China. Electronic address: weiwenbintr@163.com.
  • Fei Wang
    Department of Population Health Sciences, Weill Cornell Medicine, Cornell University, New York, NY, United States.
  • Xiangyang Gao
    Health Management Institute, The Second Medical Center & National Clinical Research Center for Geriatric Diseases, Chinese PLA General Hospital, Beijing 100853, China.
  • Yuzhong Chen
    School of Material Science and Engineering, Shandong University, Jinan, China.
  • Qiang Zeng
    State Key Laboratory of Environment Health (Incubation), Key Laboratory of Environment and Health, Ministry of Education, Key Laboratory of Environment and Health (Wuhan), Ministry of Environmental Protection, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, #13 Hangkong Road, Wuhan, Hubei 430030, China.
  • Wuxiang Xie
    Peking University Clinical Research Institute, Peking University First Hospital, Beijing 100191, China; PUCRI Heart and Vascular Health Research Center at Peking University Shougang Hospital, Beijing 100191, China; Key Laboratory of Molecular Cardiovascular Sciences (Peking University), Ministry of Education, Beijing 100191, China. Electronic address: xiewuxiang@hsc.pku.edu.cn.