AIMC Topic: Aging
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Advancements in the investigation of the mechanisms underlying cognitive aging.
Biogerontology
Aug 10, 2025
Cognitive aging, a pivotal domain at the intersection of neuroscience and psychology, exhibits a strong association with neurodegenerative disorders; however, its comprehensive underlying mechanisms remain incompletely elucidated. This review aims to...
AAGP integrates physicochemical and compositional features for machine learning-based prediction of anti-aging peptides.
Scientific reports
Aug 8, 2025
Aging is a natural phenomenon characterized by the loss of normal morphology and physiological functioning of the body, causing wrinkles on the skin, loss of hair, and compromised immune systems. Peptide therapies have emerged as a promising approach...
Chronological age estimation from human microbiomes with transformer-based Robust Principal Component Analysis.
Communications biology
Aug 6, 2025
Deep learning for microbiome analysis has shown potential for understanding microbial communities and human phenotypes. Here, we propose an approach, Transformer-based Robust Principal Component Analysis(TRPCA), which leverages the strengths of trans...
Precision nutrition in epigenetic aging: SHAP-optimized machine learning identifies omega-3 constituent-specific associations with aging biomarkers.
Biogerontology
Jul 24, 2025
This cross-sectional investigation seeks to examine the association between dietary omega-3 fatty acids (including α-linolenic acid [ALA], eicosapentaenoic acid [EPA], and docosahexaenoic acid [DHA]) and biomarkers of cellular aging, specifically DNA...
Analyses of the mechanism and therapeutic targets of senescence related genes in ischemic stroke with multi-omics approach.
Scientific reports
Jul 18, 2025
Ischemic stroke (IS) affects 11 million people annually, posing substantial clinical and economic burdens. Current therapies remain limited by time sensitivity and variable efficacy, necessitating novel biomarkers. We developed a multi-omics framewor...
Evaluating cognitive decline detection in aging populations with single-channel EEG features based on two studies and meta-analysis.
Scientific reports
Jul 15, 2025
Timely detection of cognitive decline is paramount for effective intervention, prompting researchers to leverage EEG pattern analysis, focusing particularly on cognitive load, to establish reliable markers for early detection and intervention. This c...
Protocol for the REBOUND study: a cohort study to uncover fundamental mechanisms of accelerated ageing and impaired resilience following cancer surgery and treatment.
BMC geriatrics
Jul 8, 2025
BACKGROUND: Ageing is a heterogeneous process, which is associated with heterogeneous resilience in older people. Cancer surgery and treatment may be associated with accelerated ageing in some older people; studying this process will improve understa...
Association of dietary quality, biological aging, progression and mortality of cardiovascular-kidney-metabolic syndrome: insights from mediation and machine learning approaches.
Nutrition journal
Jul 7, 2025
BACKGROUND: To investigate the association between the Dietary Inflammatory Index (DII), biological aging, and the staging and mortality of cardiovascular-kidney-metabolic (CKM) syndrome.
Nuclear morphometrics coupled with machine learning identifies dynamic states of senescence across age.
Nature communications
Jul 7, 2025
Cellular senescence is an irreversible state of cell cycle arrest with a complex role in tissue repair, aging, and disease. However, inconsistencies in identifying cellular senescence have led to varying conclusions about their functional significanc...
3BTRON: A Blood-Brain Barrier Recognition Network.
Communications biology
Jul 4, 2025
The blood-brain barrier (BBB) plays a crucial role in maintaining brain homeostasis. During ageing, the BBB undergoes structural alterations. Electron microscopy (EM) is the gold standard for studying the structural alterations of the brain vasculatu...
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