AIMC Topic: Aging
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Artificial neural network-driven approaches to improved forecasting of disability care expenditures in an aging Kingdom of Saudi Arabia population.
Scientific reports
Jul 1, 2025
The total number of older persons globally (those aged 60 years and above) was 202 million in 1950; this total multiplied to attain 901 million and is predicted to triple again in 2100. The growth percentage of the elderly population is quickly impro...
Identification of aging-related biomarkers and immune infiltration analysis in renal stones by integrated bioinformatics analysis.
Scientific reports
Jul 1, 2025
Renal stones (RS) are common urologic condition with unclear pathogenesis. Role of aging-related differentially expressed genes (ARDEGs) in RS remains poorly understood. This study aims to identify potential aging-related biomarkers for RS, explore t...
Ultradeep N-glycoproteome atlas of mouse reveals spatiotemporal signatures of brain aging and neurodegenerative diseases.
Nature communications
Jul 1, 2025
The current depth of site-specific N-glycoproteomics is insufficient to fully characterize glycosylation events in biological samples. Herein, we achieve an ultradeep and precision analysis of the N-glycoproteome of mouse tissues by integrating multi...
Role of Brain Age Gap as a Mediator in the Relationship Between Cognitive Impairment Risk Factors and Cognition.
Neurology
Jun 18, 2025
BACKGROUND AND OBJECTIVES: Cerebrovascular disease (CeVD) and cognitive impairment risk factors contribute to cognitive decline, but the role of brain age gap (BAG) in mediating this relationship remains unclear, especially in Southeast Asian populat...
Prediction of future aging-related slow gait and its determinants with deep learning and logistic regression.
PloS one
Jun 17, 2025
BACKGROUND: Identification of accelerated aging and its biomarkers can lead to more timely therapeutic interventions and decision-making. Therefore, we sought to predict aging-related slow gait, a known predictor of accelerated aging, and its determi...
Rate of brain aging associates with future executive function in Asian children and older adults.
eLife
Jun 16, 2025
Brain age has emerged as a powerful tool to understand neuroanatomical aging and its link to health outcomes like cognition. However, there remains a lack of studies investigating the rate of brain aging and its relationship to cognition. Furthermore...
Identifying a gene signature for age-related hearing loss through machine learning and revealing the effect of the CTSS on the mice cochlea.
Biogerontology
Jun 3, 2025
Age-related hearing loss (ARHL) is one of the most common health conditions among the elderly population. This study used machine learning to screen for a gene signature to predicts ARHL. Four ARHL mice cochlear transcriptome datasets and the mRNA se...
The impact of aging on achilles tendon ossification in mice.
BMC musculoskeletal disorders
May 28, 2025
BACKGROUND: Heterotopic ossification is a frequent complication of soft tissue injuries, particularly in tendons. Although ossification in tendon tissue has been reported in a range of aging and disease models, the underlying biomarkers and mechanism...
Radiomic and proteomic signatures of body mass index on brain ageing and Alzheimer's-like patterns of brain atrophy.
EBioMedicine
May 27, 2025
BACKGROUND: The impact of high body mass index (BMI) states and associated proteomic factors on brain ageing and Alzheimer's disease (AD) remains unclear.
Aging at the Crossroads of Organ Interactions: Implications for the Heart.
Circulation research
May 22, 2025
Aging processes underlie common chronic cardiometabolic diseases such as heart failure and diabetes. Cross-organ/tissue interactions can accelerate aging through cellular senescence, tissue wasting, accelerated atherosclerosis, increased vascular sti...
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