Deep Learning Image Reconstruction for CT: Technical Principles and Clinical Prospects.

Journal: Radiology
Published Date:

Abstract

Filtered back projection (FBP) has been the standard CT image reconstruction method for 4 decades. A simple, fast, and reliable technique, FBP has delivered high-quality images in several clinical applications. However, with faster and more advanced CT scanners, FBP has become increasingly obsolete. Higher image noise and more artifacts are especially noticeable in lower-dose CT imaging using FBP. This performance gap was partly addressed by model-based iterative reconstruction (MBIR). Yet, its "plastic" image appearance and long reconstruction times have limited widespread application. Hybrid iterative reconstruction partially addressed these limitations by blending FBP with MBIR and is currently the state-of-the-art reconstruction technique. In the past 5 years, deep learning reconstruction (DLR) techniques have become increasingly popular. DLR uses artificial intelligence to reconstruct high-quality images from lower-dose CT faster than MBIR. However, the performance of DLR algorithms relies on the quality of data used for model training. Higher-quality training data will become available with photon-counting CT scanners. At the same time, spectral data would greatly benefit from the computational abilities of DLR. This review presents an overview of the principles, technical approaches, and clinical applications of DLR, including metal artifact reduction algorithms. In addition, emerging applications and prospects are discussed.

Authors

  • Lennart R Koetzier
    Department of Clinical Technology, Faculty of Mechanical, Maritime, and Materials Engineering (3ME), Delft University of Technology, Mekelweg 2, NL-2628 CD, Delft, The Netherlands.
  • Domenico Mastrodicasa
    Division of Cardiovascular Imaging, Department of Radiology and Radiological Science, Medical University of South Carolina, Ashley River Tower, 25 Courtenay Dr, Charleston, SC 29425-2260 (S.S.M., D.M., M.v.A., C.N.D.C., R.R.B., C.T., A.V.S., A.M.F., B.E.J., L.P.G., U.J.S.); Department of Diagnostic and Interventional Radiology, University Hospital Frankfurt, Frankfurt, Germany (S.S.M., T.J.V.); Stanford University School of Medicine, Department of Radiology, Stanford, Calif (D.M.); Division of Cardiothoracic Imaging, Nuclear Medicine and Molecular Imaging, Department of Radiology and Imaging Sciences, Emory University, Atlanta, Ga (C.N.D.C.); Division of Cardiology, Department of Medicine, Medical University of South Carolina, Charleston, SC (R.R.B.); Department of Cardiology and Intensive Care Medicine, Heart Center Munich-Bogenhausen, Munich, Germany (C.T.); Department of Cardiology, Munich University Clinic, Ludwig-Maximilians-University, Munich, Germany (C.T.); Siemens Medical Solutions USA, Malvern, Pa (P.S.); and Department of Emergency Medicine, Medical University of South Carolina, Charleston, SC (A.J.M.).
  • Timothy P Szczykutowicz
    Department of Radiology, University of Wisconsin Madison, 1111 Highland Ave, 1005 WIMR, Madison, WI 53705.
  • Niels R van der Werf
    Department of Radiology, University Medical Center Utrecht, Heidelberglaan 100, 3584 CX, Utrecht, The Netherlands.
  • Adam S Wang
    Department of Radiology, Stanford University, Stanford, California, USA.
  • Veit Sandfort
    From the Department of Radiology, University of Wisconsin School of Medicine and Public Health, E3/311 Clinical Science Center, 600 Highland Ave, Madison, Wis 53792-3252 (P.M.G., P.J.P.); and Imaging Biomarkers and Computer-Aided Diagnosis Laboratory, Department of Radiology and Imaging Sciences, National Institutes of Health Clinical Center, Bethesda, Md (V.S., R.M.S.).
  • Aart J van der Molen
    Department of Radiology C-2S, Leiden University Medical Center, Albinusdreef 2, NL-2333 ZA, Leiden, The Netherlands.
  • Dominik Fleischmann
    Departments of Radiology (L.D.H., G.M., K.H., M.K., M.J.W., A.M.S., D.F.) and Surgery (M.F.), Stanford University School of Medicine, 300 Pasteur Dr, Room S-072, Stanford, CA 94305-5105.
  • Martin J Willemink
    Departments of Radiology (L.D.H., G.M., K.H., M.K., M.J.W., A.M.S., D.F.) and Surgery (M.F.), Stanford University School of Medicine, 300 Pasteur Dr, Room S-072, Stanford, CA 94305-5105.