Synergism of prenylflavonoids from Morus alba root bark against clinical MRSA isolates.

Journal: Phytomedicine : international journal of phytotherapy and phytopharmacology
PMID:

Abstract

BACKGROUND: Clinical methicillin-resistant Staphylococcus aureus (MRSA) is a thorny problem in current anti-infective therapeutics and a challenge of new drug development. Plant prenylflavonoids possess anti-MRSA activity, but few of the prenylflavonoids have been reported the synergistic anti-MRSA effect when they are used in combination with conventional antibacterial agents.

Authors

  • Guo-Ying Zuo
    Research Center for Natural Medicines, Kunming General Hospital of Chengdu Military Command, Kunming 650032, China. Electronic address: zuoguoying@263.net.
  • Cui-Xian Yang
    Research Center for Natural Medicines, Kunming General Hospital of Chengdu Military Command, Kunming 650032, China; School of Basic Medical Sciences, Yunnan Traditional Chinese Medical College, Kunming 650500, China.
  • Jun Han
    School of Basic Medical Sciences, Yunnan Traditional Chinese Medical College, Kunming 650500, China. Electronic address: hanzjn@126.com.
  • Yu-Qing Li
    School of Basic Medical Sciences, Yunnan Traditional Chinese Medical College, Kunming 650500, China.
  • Gen-Chun Wang
    Research Center for Natural Medicines, Kunming General Hospital of Chengdu Military Command, Kunming 650032, China.