Deep learning of protein sequence design of protein-protein interactions.
Journal:
Bioinformatics (Oxford, England)
Published Date:
Jan 1, 2023
Abstract
MOTIVATION: As more data of experimentally determined protein structures are becoming available, data-driven models to describe protein sequence-structure relationships become more feasible. Within this space, the amino acid sequence design of protein-protein interactions is still a rather challenging subproblem with very low success rates-yet, it is central to most biological processes.