A multimodal deep learning model to infer cell-type-specific functional gene networks.
Journal:
BMC bioinformatics
Published Date:
Feb 14, 2023
Abstract
BACKGROUND: Functional gene networks (FGNs) capture functional relationships among genes that vary across tissues and cell types. Construction of cell-type-specific FGNs enables the understanding of cell-type-specific functional gene relationships and insights into genetic mechanisms of human diseases in disease-relevant cell types. However, most existing FGNs were developed without consideration of specific cell types within tissues.