Requirement of image standardization for AI-based macroscopic diagnosis for surgical specimens of gastric cancer.

Journal: Journal of cancer research and clinical oncology
Published Date:

Abstract

PURPOSE: The pathological diagnosis of surgically resected gastric cancer involves both a macroscopic diagnosis by gross observation and a microscopic diagnosis by microscopy. Macroscopic diagnosis determines the location and stage of the disease and the involvement of other organs and surgical margin. Lesion recognition is, thus, an important diagnostic step that requires a skilled pathologist. Nonetheless, artificial intelligence (AI) technologies could allow even inexperienced doctors and laboratory technicians to examine surgically resected specimens without the need for pathologists. However, organ imaging conditions vary across hospitals, and an AI algorithm created in one setting may not work properly in another. Thus, we identified and standardized factors affecting the quality of pathological macroscopic images, which could further affect lesion identification using AI.

Authors

  • Shingo Sakashita
    Division of Pathology, Exploratory Oncology Research & Clinical Trial Center, National Cancer Center, Kashiwa, Chiba, Japan. ssakashi@east.ncc.go.jp.
  • Naoya Sakamoto
    Department of Gastroenterology and Hepatology, Hokkaido University Graduate School of Medicine, Sapporo 0608638, Japan.
  • Motohiro Kojima
    Division of Pathology, Exploratory Oncology Research and Clinical Trial Center, National Cancer Center, Kashiwa, 277-8577, Japan.
  • Tetsuro Taki
    Department of Pathology and Clinical Laboratories, National Cancer Center Hospital East, Kashiwa, Chiba, Japan.
  • Saori Miyazaki
    Department of Pathology and Clinical Laboratories, National Cancer Center Hospital East, Kashiwa, Chiba, Japan.
  • Nobuhisa Minakata
    Department of Gastroenterology and Endoscopy, National Cancer Center Hospital East, Kashiwa, Chiba, Japan.
  • Maasa Sasabe
    Department of Gastroenterology and Endoscopy National Cancer Center Hospital East Chiba Japan.
  • Takahiro Kinoshita
    Department of Gastric Surgery, National Cancer Center Hospital East, Kashiwa, Chiba, Japan.
  • Genichiro Ishii
    Course of Advanced Clinical Research of Cancer, Juntendo University Graduate School of Medicine, Bunkyo-ku, Tokyo, Japan.
  • Atsushi Ochiai
    Division of Pathology and Clinical Laboratories, National Cancer Center Hospital, 5-1-1 Tsukiji, Chuo-ku, Tokyo, 104-0045, Japan.