An Unsupervised Machine Learning Approach to Evaluating the Association of Symptom Clusters With Adverse Outcomes Among Older Adults With Advanced Cancer: A Secondary Analysis of a Randomized Clinical Trial.

Journal: JAMA network open
Published Date: Mar 1, 2023

Abstract

IMPORTANCE: Older adults with advanced cancer who have high pretreatment symptom severity often experience adverse events during cancer treatments. Unsupervised machine learning may help stratify patients into different risk groups.

Authors

  • Huiwen Xu
    James P. Wilmot Cancer Center, University of Rochester Medical Center, NY, USA; Department of Surgery, Cancer Control, University of Rochester Medical Center, NY, USA.
  • Mostafa Mohamed
    Department of Public Health Sciences, University of Rochester Medical Center, Rochester, New York.
  • Marie Flannery
    School of Nursing, University of Rochester Medical Center, Rochester, New York.
  • Luke Peppone
    Department of Surgery, Supportive Care in Cancer, University of Rochester Medical Center, Rochester, New York.
  • Erika Ramsdale
    James P. Wilmot Cancer Center, University of Rochester Medical Center, NY, USA. Electronic address: erika_ramsdale@urmc.rochester.edu.
  • Kah Poh Loh
    James P. Wilmot Cancer Institute, Division of Hematology/Oncology, Department of Medicine, University of Rochester Medical Center, Rochester, New York.
  • Megan Wells
    James P. Wilmot Cancer Institute, Division of Hematology/Oncology, Department of Medicine, University of Rochester Medical Center, Rochester, New York.
  • Leah Jamieson
    Metro Minnesota Community Oncology Research Program, St Louis Park, Minnesota.
  • Victor G Vogel
    Geisinger Cancer Institute National Cancer Institute Community Oncology Research Program, Danville, Pennsylvania.
  • Bianca Alexandra Hall
    James P. Wilmot Cancer Institute, Division of Hematology/Oncology, Department of Medicine, University of Rochester Medical Center, Rochester, New York.
  • Karen Mustian
    Department of Surgery, Supportive Care in Cancer, University of Rochester Medical Center, Rochester, New York.
  • Supriya Mohile
    James P. Wilmot Cancer Institute, Division of Hematology/Oncology, Department of Medicine, University of Rochester Medical Center, Rochester, New York.
  • Eva Culakova
    James P. Wilmot Cancer Center, University of Rochester Medical Center, NY, USA.

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