Combining physics-based models with deep learning image synthesis and uncertainty in intraoperative cone-beam CT of the brain.

Journal: Medical physics
Published Date:

Abstract

BACKGROUND: Image-guided neurosurgery requires high localization and registration accuracy to enable effective treatment and avoid complications. However, accurate neuronavigation based on preoperative magnetic resonance (MR) or computed tomography (CT) images is challenged by brain deformation occurring during the surgical intervention.

Authors

  • Xiaoxuan Zhang
    Department of Rheumatology and Immunology, Institute of Translational Medicine, The Affiliated Drum Tower Hospital of Nanjing University Medical School, Nanjing, 210002, China.
  • Alejandro Sisniega
    Department of Biomedical Engineering, Johns Hopkins University, Baltimore, Maryland, USA.
  • Wojciech B Zbijewski
    Department of Biomedical Engineering, Johns Hopkins University, Baltimore, Maryland, USA.
  • Junghoon Lee
    Department of Radiation Oncology and Molecular Radiation Sciences, Johns Hopkins University, Baltimore, Maryland.
  • Craig K Jones
    2Malone Center for Engineering in Healthcare, Johns Hopkins University, Baltimore; and.
  • Pengwei Wu
    Department of Biomedical Engineering, Johns Hopkins University, Baltimore, Maryland, USA.
  • Runze Han
    Department of Biomedical Engineering, Johns Hopkins University, Baltimore, Maryland, USA.
  • Ali Uneri
    Biomedical Engineering Department, Johns Hopkins University, Baltimore, MD, USA.
  • Prasad Vagdargi
    Department of Computer Science, Johns Hopkins University, Baltimore, Maryland, USA.
  • Patrick A Helm
    Medtronic Plc., Littleton, Massachusetts, USA.
  • Mark Luciano
    Department of Neurosurgery, Johns Hopkins Hospital, Baltimore, Maryland, USA.
  • William S Anderson
    Department of Neurosurgery, Johns Hopkins Hospital, Baltimore, Maryland, USA.
  • Jeffrey H Siewerdsen
    Biomedical Engineering Department, Johns Hopkins University, Baltimore, MD, USA.