A deep learning-based technique for the diagnosis of epidural spinal cord compression on thoracolumbar CT.

Journal: European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society
PMID: 37093263

Abstract

PURPOSE: To develop a deep learning (DL) model for epidural spinal cord compression (ESCC) on CT, which will aid earlier ESCC diagnosis for less experienced clinicians.

Authors

  • James Thomas Patrick Decourcy Hallinan
    From the Department of Diagnostic Imaging, National University Hospital, 5 Lower Kent Ridge Rd, Singapore 119074 (J.T.P.D.H., A.M., Y.L.T., S.L., Y.S.C., S.E.E., S.T.Q.); Department of Diagnostic Radiology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore (J.T.P.D.H., A.M., Y.L.T., S.L., Y.S.C., S.E.E., S.T.Q.); NUS Graduate School, Integrative Sciences and Engineering Programme, National University of Singapore, Singapore (L.Z.); Department of Computer Science, School of Computing, National University of Singapore, Singapore (K.Y., B.C.O.); Department of Radiology, Dammam Medical Complex, Dammam, Saudi Arabia (D.A.R.A.); Biostatistics Unit, Yong Loo Lin School of Medicine, Singapore (Q.V.Y., Y.H.C.); University Spine Centre, Department of Orthopaedic Surgery, National University Health System, Singapore (J.H.T., N.K.); and Department of Radiological Sciences, University of California, Irvine, Orange, Calif (H.Y.).
  • Lei Zhu
    School of Civil and Hydraulic Engineering, Ningxia University, Yinchuan, China.
  • Hui Wen Natalie Tan
    Department of Orthopaedic Surgery, University Spine Centre, National University Health System, 1E, Lower Kent Ridge Road, Singapore, 119228, Singapore.
  • Si Jian Hui
    Department of Orthopaedic Surgery, University Spine Centre, National University Health System, 1E, Lower Kent Ridge Road, Singapore, 119228, Singapore.
  • Xinyi Lim
    Orthopaedic Centre, Alexandra Hospital, 378 Alexandra Road, Singapore, 159964, Singapore.
  • Bryan Wei Loong Ong
    Department of Orthopaedic Surgery, University Spine Centre, National University Health System, 1E, Lower Kent Ridge Road, Singapore, 119228, Singapore.
  • Han Yang Ong
    From the Department of Diagnostic Imaging, National University Hospital, 5 Lower Kent Ridge Rd, Singapore 119074 (D.S.W.L., A.M., A.J.L.C., D.S.Y.S., S.E.E., H.Y.O., P.J., W.C.T., V.M.K., Y.M.W., Y.L.T., S.B., E.C.T., S.T.Q., J.T.P.D.H.); Department of Diagnostic Radiology (A.M., S.E.E., P.J., Y.L.T., S.T.Q., J.T.P.D.H.), NUS Graduate School, Integrative Sciences and Engineering Programme (L.Z.), Department of Computer Science, School of Computing (W.Z., B.C.O.), and Biostatistics Unit, Yong Loo Lin School of Medicine (Q.V.Y., Y.H.C.), National University of Singapore, Singapore; Department of Radiology, Qatif Central Hospital, Qatif, Saudi Arabia (D.A.R.A.); Department of Orthopaedic Surgery, National University Health System, Singapore (J.H.T., N.K.); and Department of Radiological Sciences, University of California, Irvine, Orange, Calif (H.Y.).
  • Sterling Ellis Eide
    From the Department of Diagnostic Imaging, National University Hospital, 5 Lower Kent Ridge Rd, Singapore 119074 (J.T.P.D.H., A.M., Y.L.T., S.L., Y.S.C., S.E.E., S.T.Q.); Department of Diagnostic Radiology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore (J.T.P.D.H., A.M., Y.L.T., S.L., Y.S.C., S.E.E., S.T.Q.); NUS Graduate School, Integrative Sciences and Engineering Programme, National University of Singapore, Singapore (L.Z.); Department of Computer Science, School of Computing, National University of Singapore, Singapore (K.Y., B.C.O.); Department of Radiology, Dammam Medical Complex, Dammam, Saudi Arabia (D.A.R.A.); Biostatistics Unit, Yong Loo Lin School of Medicine, Singapore (Q.V.Y., Y.H.C.); University Spine Centre, Department of Orthopaedic Surgery, National University Health System, Singapore (J.H.T., N.K.); and Department of Radiological Sciences, University of California, Irvine, Orange, Calif (H.Y.).
  • Amanda J L Cheng
    From the Department of Diagnostic Imaging, National University Hospital, 5 Lower Kent Ridge Rd, Singapore 119074 (D.S.W.L., A.M., A.J.L.C., D.S.Y.S., S.E.E., H.Y.O., P.J., W.C.T., V.M.K., Y.M.W., Y.L.T., S.B., E.C.T., S.T.Q., J.T.P.D.H.); Department of Diagnostic Radiology (A.M., S.E.E., P.J., Y.L.T., S.T.Q., J.T.P.D.H.), NUS Graduate School, Integrative Sciences and Engineering Programme (L.Z.), Department of Computer Science, School of Computing (W.Z., B.C.O.), and Biostatistics Unit, Yong Loo Lin School of Medicine (Q.V.Y., Y.H.C.), National University of Singapore, Singapore; Department of Radiology, Qatif Central Hospital, Qatif, Saudi Arabia (D.A.R.A.); Department of Orthopaedic Surgery, National University Health System, Singapore (J.H.T., N.K.); and Department of Radiological Sciences, University of California, Irvine, Orange, Calif (H.Y.).
  • Shuliang Ge
    Department of Diagnostic Imaging, National University Hospital, 5 Lower Kent Ridge Rd, Singapore, 119074, Singapore.
  • Tricia Kuah
    Department of Diagnostic Imaging, National University Hospital, 5 Lower Kent Ridge Rd, Singapore, 119074, Singapore.
  • Shi Wei Desmond Lim
    Department of Diagnostic Imaging, National University Hospital, 5 Lower Kent Ridge Rd, Singapore, 119074, Singapore.
  • Xi Zhen Low
    Department of Diagnostic Imaging, National University Hospital, 5 Lower Kent Ridge Rd, Singapore, 119074, Singapore.
  • Ee Chin Teo
    From the Department of Diagnostic Imaging, National University Hospital, 5 Lower Kent Ridge Rd, Singapore 119074 (D.S.W.L., A.M., A.J.L.C., D.S.Y.S., S.E.E., H.Y.O., P.J., W.C.T., V.M.K., Y.M.W., Y.L.T., S.B., E.C.T., S.T.Q., J.T.P.D.H.); Department of Diagnostic Radiology (A.M., S.E.E., P.J., Y.L.T., S.T.Q., J.T.P.D.H.), NUS Graduate School, Integrative Sciences and Engineering Programme (L.Z.), Department of Computer Science, School of Computing (W.Z., B.C.O.), and Biostatistics Unit, Yong Loo Lin School of Medicine (Q.V.Y., Y.H.C.), National University of Singapore, Singapore; Department of Radiology, Qatif Central Hospital, Qatif, Saudi Arabia (D.A.R.A.); Department of Orthopaedic Surgery, National University Health System, Singapore (J.H.T., N.K.); and Department of Radiological Sciences, University of California, Irvine, Orange, Calif (H.Y.).
  • Qai Ven Yap
    From the Department of Diagnostic Imaging, National University Hospital, 5 Lower Kent Ridge Rd, Singapore 119074 (J.T.P.D.H., A.M., Y.L.T., S.L., Y.S.C., S.E.E., S.T.Q.); Department of Diagnostic Radiology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore (J.T.P.D.H., A.M., Y.L.T., S.L., Y.S.C., S.E.E., S.T.Q.); NUS Graduate School, Integrative Sciences and Engineering Programme, National University of Singapore, Singapore (L.Z.); Department of Computer Science, School of Computing, National University of Singapore, Singapore (K.Y., B.C.O.); Department of Radiology, Dammam Medical Complex, Dammam, Saudi Arabia (D.A.R.A.); Biostatistics Unit, Yong Loo Lin School of Medicine, Singapore (Q.V.Y., Y.H.C.); University Spine Centre, Department of Orthopaedic Surgery, National University Health System, Singapore (J.H.T., N.K.); and Department of Radiological Sciences, University of California, Irvine, Orange, Calif (H.Y.).
  • Yiong Huak Chan
    From the Department of Diagnostic Imaging, National University Hospital, 5 Lower Kent Ridge Rd, Singapore 119074 (J.T.P.D.H., A.M., Y.L.T., S.L., Y.S.C., S.E.E., S.T.Q.); Department of Diagnostic Radiology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore (J.T.P.D.H., A.M., Y.L.T., S.L., Y.S.C., S.E.E., S.T.Q.); NUS Graduate School, Integrative Sciences and Engineering Programme, National University of Singapore, Singapore (L.Z.); Department of Computer Science, School of Computing, National University of Singapore, Singapore (K.Y., B.C.O.); Department of Radiology, Dammam Medical Complex, Dammam, Saudi Arabia (D.A.R.A.); Biostatistics Unit, Yong Loo Lin School of Medicine, Singapore (Q.V.Y., Y.H.C.); University Spine Centre, Department of Orthopaedic Surgery, National University Health System, Singapore (J.H.T., N.K.); and Department of Radiological Sciences, University of California, Irvine, Orange, Calif (H.Y.).
  • Naresh Kumar
    Department of Computer Science & Engineering, Maharaja Surajmal Institute of Technology, C-4, Janakpuri, New Delhi 110058, India.
  • Balamurugan A Vellayappan
    Department of Radiation Oncology, National University Cancer Institute Singapore, National University Hospital, Singapore, Singapore.
  • Beng Chin Ooi
    School of Computing, National University of Singapore, Singapore, Singapore.
  • Swee Tian Quek
    From the Department of Diagnostic Imaging, National University Hospital, 5 Lower Kent Ridge Rd, Singapore 119074 (J.T.P.D.H., A.M., Y.L.T., S.L., Y.S.C., S.E.E., S.T.Q.); Department of Diagnostic Radiology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore (J.T.P.D.H., A.M., Y.L.T., S.L., Y.S.C., S.E.E., S.T.Q.); NUS Graduate School, Integrative Sciences and Engineering Programme, National University of Singapore, Singapore (L.Z.); Department of Computer Science, School of Computing, National University of Singapore, Singapore (K.Y., B.C.O.); Department of Radiology, Dammam Medical Complex, Dammam, Saudi Arabia (D.A.R.A.); Biostatistics Unit, Yong Loo Lin School of Medicine, Singapore (Q.V.Y., Y.H.C.); University Spine Centre, Department of Orthopaedic Surgery, National University Health System, Singapore (J.H.T., N.K.); and Department of Radiological Sciences, University of California, Irvine, Orange, Calif (H.Y.).
  • Andrew Makmur
    From the Department of Diagnostic Imaging, National University Hospital, 5 Lower Kent Ridge Rd, Singapore 119074 (J.T.P.D.H., A.M., Y.L.T., S.L., Y.S.C., S.E.E., S.T.Q.); Department of Diagnostic Radiology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore (J.T.P.D.H., A.M., Y.L.T., S.L., Y.S.C., S.E.E., S.T.Q.); NUS Graduate School, Integrative Sciences and Engineering Programme, National University of Singapore, Singapore (L.Z.); Department of Computer Science, School of Computing, National University of Singapore, Singapore (K.Y., B.C.O.); Department of Radiology, Dammam Medical Complex, Dammam, Saudi Arabia (D.A.R.A.); Biostatistics Unit, Yong Loo Lin School of Medicine, Singapore (Q.V.Y., Y.H.C.); University Spine Centre, Department of Orthopaedic Surgery, National University Health System, Singapore (J.H.T., N.K.); and Department of Radiological Sciences, University of California, Irvine, Orange, Calif (H.Y.).
  • Jiong Hao Tan
    From the Department of Diagnostic Imaging, National University Hospital, 5 Lower Kent Ridge Rd, Singapore 119074 (J.T.P.D.H., A.M., Y.L.T., S.L., Y.S.C., S.E.E., S.T.Q.); Department of Diagnostic Radiology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore (J.T.P.D.H., A.M., Y.L.T., S.L., Y.S.C., S.E.E., S.T.Q.); NUS Graduate School, Integrative Sciences and Engineering Programme, National University of Singapore, Singapore (L.Z.); Department of Computer Science, School of Computing, National University of Singapore, Singapore (K.Y., B.C.O.); Department of Radiology, Dammam Medical Complex, Dammam, Saudi Arabia (D.A.R.A.); Biostatistics Unit, Yong Loo Lin School of Medicine, Singapore (Q.V.Y., Y.H.C.); University Spine Centre, Department of Orthopaedic Surgery, National University Health System, Singapore (J.H.T., N.K.); and Department of Radiological Sciences, University of California, Irvine, Orange, Calif (H.Y.).

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