Development and validation of an automatic classification algorithm for the diagnosis of Alzheimer's disease using a high-performance interpretable deep learning network.

Journal: European radiology
PMID:

Abstract

OBJECTIVES: To develop and validate an automatic classification algorithm for diagnosing Alzheimer's disease (AD) or mild cognitive impairment (MCI).

Authors

  • Ho Young Park
    Department of Radiology and Research Institute of Radiology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea.
  • Woo Hyun Shim
    Department of Radiology and Research Institute of Radiology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea.
  • Chong Hyun Suh
    Department of Radiology and Research Institute of Radiology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea.
  • Hwon Heo
    Department of Radiology and Research Institute of Radiology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea.
  • Hyun Woo Oh
    VUNO Inc., Seoul, Republic of Korea.
  • Jinyoung Kim
    R&D Center, VUNO, Seoul, Republic of Korea.
  • Jinkyeong Sung
    From the R&D Center, VUNO, 507 Gangnamdae-ro, Seocho-gu, Seoul 06536, South Korea (J.S., W.B., B.P., E.J., K.H.J.); and Department of Radiology, University of Ulsan College of Medicine, Asan Medical Center, Seoul, South Korea (S.P., S.M.L., J.B.S.).
  • Jae-Sung Lim
    Department of Neurology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea.
  • Jae-Hong Lee
    Department of Neurology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea.
  • Ho Sung Kim
    Department of Radiology and Research Institute of Radiology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea.
  • Sang Joon Kim
    Department of Radiology and Research Institute of Radiology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea.