Proceedings of the National Academy of Sciences of the United States of America
Dec 10, 2025
Social information processing involves coordinated neural activity across distributed brain circuits, with the ventral hippocampus (vHPC) and medial prefrontal cortex (mPFC) playing pivotal roles. However, whether these regions employ distinct coding...
The environmental pollutant Benzo[a]pyrene (B[a]P) and its ultimate metabolite B[a]P-7,8-diol-9,10-epoxide (BPDE) exhibit neurotoxic effects, yet the underlying molecular mechanisms remain enigmatic. Recently, ferroptosis has emerged as a potential p...
Sleep-wake states bidirectionally interact with epilepsy and seizures, but the mechanisms are unknown. A barrier to comprehensive characterization and the study of mechanisms has been the difficulty of annotating large chronic recording datasets. To ...
The Journal of neuroscience : the official journal of the Society for Neuroscience
Oct 8, 2025
In temporal lobe epilepsy, interictal spikes (IS)-hyper-synchronous bursts of network activity-occur at high rates in between seizures. We sought to understand the influence of IS on working memory by recording hippocampal local field potentials from...
The rostral anterior cingulate cortex (rACC) has been identified as a key region in treatment-resistant depression (TRD), potentially influencing the adaptive interplay between the default mode network and other critical neural networks. This study a...
Identifying the computational roles of different neuron families is crucial for understanding neural networks. Most neural diversity is embodied in various types of γ-aminobutyric acid-mediated (GABAergic) interneurons, grouped into four major famili...
BACKGROUND: Depression is a prevalent mental disorder, and prolonged exposure to social defeat is a major contributing factor in the onset of depression. Repeated social defeat stress (RSDS) is a commonly used animal model for depression, significant...
Analytical methods : advancing methods and applications
Aug 21, 2025
Dry eye disease (DED) and depression exhibit high comorbidity, yet lipid and purine diagnostic biomarkers for depression-related DED remain unidentified. In this study, matrix-assisted laser desorption/ionization mass spectrometry imaging (MALDI-MSI)...
How do humans construct mental representations of social hierarchies in the absence of direct interpersonal interactions? In many real-world contexts, humans rely on symbolic rank labels-such as titles or performance ratings-to navigate social hierar...
Proceedings of the National Academy of Sciences of the United States of America
Jul 7, 2025
This research investigates the neurophysiological mechanisms of experiential versus monetary choices under risk. While ventral striatum and insula activity are instrumental in predicting monetary choices, we find that hippocampal activity plays a key...
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