Data infrastructures for AI in medical imaging: a report on the experiences of five EU projects.

Journal: European radiology experimental
Published Date:

Abstract

Artificial intelligence (AI) is transforming the field of medical imaging and has the potential to bring medicine from the era of 'sick-care' to the era of healthcare and prevention. The development of AI requires access to large, complete, and harmonized real-world datasets, representative of the population, and disease diversity. However, to date, efforts are fragmented, based on single-institution, size-limited, and annotation-limited datasets. Available public datasets (e.g., The Cancer Imaging Archive, TCIA, USA) are limited in scope, making model generalizability really difficult. In this direction, five European Union projects are currently working on the development of big data infrastructures that will enable European, ethically and General Data Protection Regulation-compliant, quality-controlled, cancer-related, medical imaging platforms, in which both large-scale data and AI algorithms will coexist. The vision is to create sustainable AI cloud-based platforms for the development, implementation, verification, and validation of trustable, usable, and reliable AI models for addressing specific unmet needs regarding cancer care provision. In this paper, we present an overview of the development efforts highlighting challenges and approaches selected providing valuable feedback to future attempts in the area.Key points• Artificial intelligence models for health imaging require access to large amounts of harmonized imaging data and metadata.• Main infrastructures adopted either collect centrally anonymized data or enable access to pseudonymized distributed data.• Developing a common data model for storing all relevant information is a challenge.• Trust of data providers in data sharing initiatives is essential.• An online European Union meta-tool-repository is a necessity minimizing effort duplication for the various projects in the area.

Authors

  • Haridimos Kondylakis
    Computational BioMedicine Laboratory, FORTH-ICS, Heraklion, Crete, Greece.
  • Varvara Kalokyri
    FORTH-ICS, N Plastira 100, Heraklion, Crete, Greece.
  • Stelios Sfakianakis
    Foundation for Research and Technology Hellas (FORTH), Institute of Computer Science, N. Plastira 100, Vassilika Vouton, Heraklion, Crete, Greece.
  • Kostas Marias
    Computational BioMedicine Laboratory, FORTH-ICS, Heraklion, Crete, Greece.
  • Manolis Tsiknakis
    Computational BioMedicine Laboratory, FORTH-ICS, Heraklion, Crete, Greece.
  • Ana Jimenez-Pastor
    QUIBIM SL, Valencia, Spain. anajimenez@quibim.com.
  • Eduardo Camacho-Ramos
    Quibim SL, Valencia, Spain.
  • Ignacio Blanquer
    Instituto de Instrumentación para Imagen Molecular (I3M), Universitat Politècnica de València (UPV), c\ Camino de Vera s/n, 46022, Valencia, Spain.
  • J Damian Segrelles
    Instituto de Instrumentación para Imagen Molecular (I3M), Universitat Politècnica de València (UPV), c\ Camino de Vera s/n, 46022, Valencia, Spain.
  • Sergio López-Huguet
    Universitat Politècnica de València, Valencia, Spain.
  • Caroline Barelle
    European Dynamics, Maroussi, Athens, Greece.
  • Magdalena Kogut-Czarkowska
    Timelex CVBA, Brussels, Belgium.
  • Gianna Tsakou
    MAGGIOLI S.P.A., Research and Development Lab, Marousi, Greece.
  • Nikolaos Siopis
    Centre of Research & Technology - Hellas, Information Technologies Institute, Thermi - Thessaloniki, Greece.
  • Zisis Sakellariou
    Centre of Research & Technology - Hellas, Information Technologies Institute, Thermi - Thessaloniki, Greece.
  • Paschalis Bizopoulos
  • Vicky Drossou
    Centre of Research & Technology - Hellas, Information Technologies Institute, Thermi - Thessaloniki, Greece.
  • Antonios Lalas
    Centre of Research & Technology - Hellas, Information Technologies Institute, Thermi - Thessaloniki, Greece.
  • Konstantinos Votis
  • Pedro Mallol
    La Fe Health Research Institute, Valencia, Spain.
  • Luis Marti-Bonmati
    QUIBIM SL, Valencia, Spain.
  • Leonor Cerdá Alberich
    La Fe Health Research Institute, Valencia, Spain.
  • Karine Seymour
    Medexprim, 815 La Pyrénéenne, 31670, Labège, France.
  • Samuel Boucher
    Medexprim, Labège, France.
  • Esther Ciarrocchi
    Università di Pisa, Dipartimento di Fisica E. Fermi, Italy.
  • Lauren Fromont
    European Genome-Phenome Archive, Centre for Genomic Regulation, Barcelona, Spain.
  • Jordi Rambla
    European Genome-Phenome Archive, Centre for Genomic Regulation, Barcelona, Spain.
  • Alexander Harms
    Erasmus MC, Rotterdam, The Netherlands.
  • Andrea Gutierrez
    Erasmus MC, Rotterdam, The Netherlands.
  • Martijn P A Starmans
    Biomedical Imaging Group Rotterdam, Departments of Radiology and Nuclear Medicine Medical Informatics, Erasmus MC-University Medical Centre Rotterdam, Rotterdam, the Netherlands.
  • Fred Prior
    Department of Biomedical Informatics, University of Arkansas for Medical Sciences (UAMS), Little Rock, AR, United States.
  • Josep Ll Gelpi
    University of Barcelona, Barcelona, Spain.
  • Karim Lekadir
    Information and Communication Technologies Department, Universitat Pompeu Fabra, Barcelona, Spain.