Characteristics of Long-term Nonprogressors and Viremia Controllers Infected with HIV-1 via Contaminated Blood Donations or Transfusions Conducted 20 Years Earlier.

Journal: Biomedical and environmental sciences : BES
PMID: 29335060

Abstract

To characterize long-term nonprogressors (LTNPs) and viremia controllers (VCs), infected with HIV-1 through contaminated blood donation or transfusion between 1992 and 1996 in Henan, China. LTNPs and VCs were defined by CD4+T lymphocyte (CD4) count and viral load (VL). Of 29,294 patients infected with HIV-1 via contaminated blood donation or transfusion that had conducted for more than 20 years, 92 were LTNPs/VCs. There were 70 LTNPs (0.24%), 43 VCs (0.15%), and 48 LTNPs+VCs- (0.16%). VCs had a significantly lower CD4 nadir, compared to LTNPs and LTNPs+VCs-, and no significant differences for the highest VL and HIV-1 DNA. Cases P4 and P5 were LTNPs, while their VL reached approximately 4.3 log copies/mL. P6 was a VC, but with CD4 < 500 cells/μL constantly. Data from the LTNPs/VCs cohort provided valuable information, future research is needed.

Authors

  • Jia Liu
    Department of Colorectal Oncology, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Tianjin's Clinical Research Center for Cancer, Tianjin Key Laboratory of Digestive Cancer, Tianjin, China.
  • Pan Ying Fan
    Institute for Prevention and Control of AIDS and STD, Henan Center for Disease Control and Prevention, Zhengzhou 450016, Henan, China.
  • Xiu Juan Xue
    Institute for Prevention and Control of AIDS and STD, Henan Center for Disease Control and Prevention, Zhengzhou 450016, Henan, China.
  • Jiang Zhou Yan
    Institute for Prevention and Control of AIDS and STD, Henan Center for Disease Control and Prevention, Zhengzhou 450016, Henan, China.
  • Guo Qing Sun
    Institute for Prevention and Control of AIDS and STD, Henan Center for Disease Control and Prevention, Zhengzhou 450016, Henan, China.
  • Chun Hua Liu
    Institute for Prevention and Control of AIDS and STD, Henan Center for Disease Control and Prevention, Zhengzhou 450016, Henan, China.
  • Sui An Tian
    Institute for Prevention and Control of AIDS and STD, Henan Center for Disease Control and Prevention, Zhengzhou 450016, Henan, China.
  • Ning Li
    Department of Respiratory and Critical Care Medicine, Center for Respiratory Medicine, the Fourth Affiliated Hospital of School of Medicine, and International School of Medicine, International Institutes of Medicine, Zhejiang University, Yiwu, China.
  • Ding Yong Sun
    Institute for Prevention and Control of AIDS and STD, Henan Center for Disease Control and Prevention, Zhengzhou 450016, Henan, China.
  • Qian Zhu
    Institute for Prevention and Control of AIDS and STD, Henan Center for Disease Control and Prevention, Zhengzhou 450016, Henan, China.
  • Zhe Wang
    Department of Pathology, The Eighth Affiliated Hospital, Sun Yat-sen University, Shenzhen 518033, China.

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