Artificial Intelligence Applied to a First Screening of Naevoid Melanoma: A New Use of Fast Random Forest Algorithm in Dermatopathology.

Journal: Current oncology (Toronto, Ont.)
Published Date:

Abstract

Malignant melanoma (MM) is the "great mime" of dermatopathology, and it can present such rare variants that even the most experienced pathologist might miss or misdiagnose them. Naevoid melanoma (NM), which accounts for about 1% of all MM cases, is a constant challenge, and when it is not diagnosed in a timely manner, it can even lead to death. In recent years, artificial intelligence has revolutionised much of what has been achieved in the biomedical field, and what once seemed distant is now almost incorporated into the diagnostic therapeutic flow chart. In this paper, we present the results of a machine learning approach that applies a fast random forest (FRF) algorithm to a cohort of naevoid melanomas in an attempt to understand if and how this approach could be incorporated into the business process modelling and notation (BPMN) approach. The FRF algorithm provides an innovative approach to formulating a clinical protocol oriented toward reducing the risk of NM misdiagnosis. The work provides the methodology to integrate FRF into a mapped clinical process.

Authors

  • Gerardo Cazzato
    Dipartimento dell'Emergenza e dei Trapianti di Organi, Università degli Studi di Bari "Aldo Moro", Bari, Italy.
  • Alessandro Massaro
    Università LUM "Giuseppe Degennaro", S.S. 100-km 18, Casamassima, 70010 Bari, Italy.
  • Anna Colagrande
    Section of Pathology, Department of Precision and Regenerative Medicine and Ionian Area (DiMePRe-J), University of Bari "Aldo Moro", 70124 Bari, Italy.
  • Irma Trilli
    Odontomatostologic Clinic, Department of Innovative Technologies in Medicine and Dentistry, University of Chieti "G. D'Annunzio", 66100 Chieti, Italy.
  • Giuseppe Ingravallo
    Section of Pathology, Department of Precision and Regenerative Medicine and Ionian Area (DiMePRe-J), University of Bari "Aldo Moro", 70124 Bari, Italy.
  • Nadia Casatta
    Innovation Department, Diapath S.p.A., Via Savoldini n.71, 24057 Martinengo, Italy.
  • Carmelo Lupo
    Innovation Department, Diapath S.p.A., Via Savoldini n.71, 24057 Martinengo, Italy.
  • Andrea Ronchi
    Pathology Unit, Department of Mental Health and Physic and Preventive Medicine, University of Campania "Luigi Vanvitelli", 80138 Naples, Italy.
  • Renato Franco
    Pathology Unit, Department of Mental Health and Physic and Preventive Medicine, University of Campania "Luigi Vanvitelli", 80138 Naples, Italy.
  • Eugenio Maiorano
    Section of Pathology, Department of Precision and Regenerative Medicine and Ionian Area (DiMePRe-J), University of Bari "Aldo Moro", 70124 Bari, Italy.
  • Angelo Vacca
    Centro Interdisciplinare Ricerca Telemedicina-CITEL, Università degli Studi di Bari "Aldo Moro", 70124 Bari, Italy.