BACKGROUND: Although immune checkpoint inhibitor (ICI) represents a significant breakthrough in cancer immunotherapy, only a few patients benefit from it. Given the critical role of Treg cells in ICI treatment resistance, we explored a Treg-associate...
INTRODUCTION: The gut microbiota is associated with the response to immunotherapy in cutaneous melanoma (CM). However, gut fungal biomarkers and bacterial-fungal interactions have yet to be determined.
BACKGROUND: Prognostic histopathological features such as mitosis in melanoma are excluded from the staging systems due to inter-observer variability and time constraints. While digital pathology offers artificial intelligence-driven solutions, exist...
Immune checkpoint inhibitors (ICIs) have transformed melanoma treatment; however, predicting patient responses remains a significant challenge. This study reviews the potential of artificial intelligence (AI) to optimize ICI therapy in melanoma by in...
Melanoma skin cancer is a deadly disease with a high mortality rate. A prompt diagnosis can aid in the treatment of the disease and potentially save the patient's life. Artificial intelligence methods can help diagnose cancer at a rapid speed. The li...
Skin cancer represents a significant global public health issue, and prompt and precise detection is essential for effective treatment. This study introduces SkinEHDLF, an innovative deep-learning model that enhances skin cancer classification. SkinE...
OBJECTIVE: The assessment of immunotherapy plays a pivotal role in the clinical management of skin melanoma. Graph neural networks (GNNs), alongside other deep learning algorithms and bioinformatics approaches, have demonstrated substantial promise i...
BACKGROUND: Melanoma (SKCM) is an extremely aggressive form of cancer, characterized by high mortality rates, frequent metastasis, and limited treatment options. Our study aims to identify key target genes and enhance the diagnostic accuracy of melan...
Computer methods and programs in biomedicine
40184849
BACKGROUND: The clinical diagnosis of skin lesions involves the analysis of dermoscopic and clinical modalities. Dermoscopic images provide detailed views of surface structures, while clinical images offer complementary macroscopic information. Clini...
PURPOSE: The use of real-world data (RWD) in oncology is becoming increasingly important for clinical decision making and tailoring treatment. Despite the significant success of targeted therapy and immunotherapy in advanced melanoma, substantial var...