One-pot multicomponent synthesis of novel pyridine derivatives for antidiabetic and antiproliferative activities.

Journal: Future medicinal chemistry
PMID: 37503685

Abstract

Due to the close relationship of diabetes with hypertension reported in various research, a set of pyridine derivatives with US FDA-approved drug cores were designed and integrated by artificial intelligence. Novel pyridines were designed and synthesized. Compounds - were evaluated for their structure and were screened for their antidiabetic (α-amylase) activity and anticancer (HepG2) activity by methyl thiazolyl tetrazolium assay. Comparative 3D quantitative structure-activity relationship analysis and pharmacophore generation were carried out. The study revealed and as good alternatives to acarbose as antidiabetic agents, and as a more viable, better alternative to doxorubicin in the methyl thiazolyl tetrazolium assay. This combination of studies identifies new and more active analogs of existing FDA-approved drugs for the treatment of diabetes.

Authors

  • Nusrat Shafiq
    Synthetic & Natural Product Discovery Laboratory, Department of Chemistry, Government College Women's University Faisalabad, 38000, Pakistan.
  • Nabeel Shahzad
    Department of Chemistry, University of WAH, Wah Cantt, 44700, Pakistan.
  • Fatima Rida
    Synthetic & Natural Product Discovery Laboratory, Department of Chemistry, Government College Women's University Faisalabad, 38000, Pakistan.
  • Zaheer Ahmad
    Department of Computer Science, COMSATS University Islamabad, Islamabad, Pakistan.
  • Hafiza Ayesha Nazir
    Synthetic & Natural Product Discovery Laboratory, Department of Chemistry, Government College Women's University Faisalabad, 38000, Pakistan.
  • Uzma Arshad
    Synthetic & Natural Product Discovery Laboratory, Department of Chemistry, Government College Women's University Faisalabad, 38000, Pakistan.
  • Gul Zareen
    Synthetic & Natural Product Discovery Laboratory, Department of Chemistry, Government College Women's University Faisalabad, 38000, Pakistan.
  • Naila Attiq
    Synthetic & Natural Product Discovery Laboratory, Department of Chemistry, Government College Women's University Faisalabad, 38000, Pakistan.
  • Shagufta Parveen
    Synthetic & Natural Product Discovery Laboratory, Department of Chemistry, Government College Women's University Faisalabad, 38000, Pakistan.
  • Maryam Rashid
    Synthetic & Natural Product Discovery Laboratory, Department of Chemistry, Government College Women's University Faisalabad, 38000, Pakistan.
  • Basharat Ali
    Department of Chemistry, Khawaja Fareed University of Engineering & Information Technology, Rahim Yar Khan, Punjab, 64200, Pakistan.

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