AIMC Topic: Hypoglycemic Agents
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Research Gaps, Challenges, and Opportunities in Automated Insulin Delivery Systems.
Journal of diabetes science and technology
Jul 1, 2025
BACKGROUND: Since the discovery of the life-saving hormone insulin in 1921 by Dr Frederick Banting in 1921, there have been many critical discoveries and technical breakthroughs that have enabled people living with type 1 diabetes (T1D) to live longe...
Chemical Properties-Based Deep Learning Models for Recommending Rational Daily Diet Combinations to Diabetics Through Large-Scale Virtual Screening of α-Glucosidase Dietary-Derived Inhibitors and Verified In Vitro.
Journal of agricultural and food chemistry
Jun 5, 2025
The lack of suitable chemical research methodologies has hindered the discovery of rational daily diet combinations from large-scale dietary-derived compounds. Three deep learning models based on chemical properties for α-glucosidase inhibitors (AGIs...
Enhancing Antidiabetic Drug Selection Using Transformers: Machine-Learning Model Development.
JMIR medical informatics
Jun 2, 2025
BACKGROUND: Diabetes affects millions worldwide. Primary care physicians provide a significant portion of care, and they often struggle with selecting appropriate medications.
Machine learning applications to classify and monitor medication adherence in patients with type 2 diabetes in Ethiopia.
Frontiers in endocrinology
Mar 20, 2025
BACKGROUND: Medication adherence plays a crucial role in determining the health outcomes of patients, particularly those with chronic conditions like type 2 diabetes. Despite its significance, there is limited evidence regarding the use of machine le...
SERPINA3: A Novel Therapeutic Target for Diabetes-Related Cognitive Impairment Identified Through Integrated Machine Learning and Molecular Docking Analysis.
International journal of molecular sciences
Feb 24, 2025
Diabetes-related cognitive impairment (DCI) is a severe complication of type 2 diabetes mellitus (T2DM), with limited understanding of its molecular mechanisms hindering effective therapeutic development. This study identified SERPINA3 as a potential...
Food-derived DPP4 inhibitors: Drug discovery based on high-throughput virtual screening and deep learning.
Food chemistry
Feb 21, 2025
Dipeptidyl peptidase-4 (DPP-4) is a critical target for the treatment of type 2 diabetes. This study outlines the development of six compounds derived from food sources and modified to create promising candidates for the treatment of diabetes. These ...
A safe-enhanced fully closed-loop artificial pancreas controller based on deep reinforcement learning.
PloS one
Jan 27, 2025
Patients with type 1 diabetes and their physicians have long desired a fully closed-loop artificial pancreas (AP) system that can alleviate the burden of blood glucose regulation. Although deep reinforcement learning (DRL) methods theoretically enabl...
Predictors of glycaemic improvement in children and young adults with type 1 diabetes and very elevated HbA1c using the MiniMed 780G system.
Diabetes, obesity & metabolism
Jan 20, 2025
AIMS: This study aimed to identify key factors with the greatest influence on glycaemic outcomes in young individuals with type 1 diabetes (T1D) and very elevated glycaemia after 3 months of automated insulin delivery (AID).
AntiT2DMP-Pred: Leveraging feature fusion and optimization for superior machine learning prediction of type 2 diabetes mellitus.
Methods (San Diego, Calif.)
Jan 10, 2025
Pancreatic α-amylase breaks down starch into isomaltose and maltose, which are further hydrolyzed by α-glucosidase in the intestine into monosaccharides, rapidly raising blood sugar levels and contributing to type 2 diabetes mellitus (T2DM). Syntheti...
The effect of renal function on the clinical outcomes and management of patients hospitalized with hyperglycemic crises.
Frontiers in endocrinology
Jan 9, 2025
BACKGROUND: The global prevalence of diabetes has been rising rapidly in recent years, leading to an increase in patients experiencing hyperglycemic crises like diabetic ketoacidosis (DKA) and hyperosmolar hyperglycemic state (HHS). Patients with imp...
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