AIMC Topic: Pyridines
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Design, synthesis, and evaluation of triazolo[1,5-a]pyridines as novel and potent α‑glucosidase inhibitors.
Scientific reports
May 22, 2025
α-Glucosidase is a key enzyme responsible for controlling the blood glucose, making a pivotal target in the treatment of type 2 diabetes mellitus. Present work introducestriazolo[1,5-a]pyridine as a novel, potent scaffold for α-glucosidase inhibition...
Butyric acid alleviates LPS-induced intestinal mucosal barrier damage by inhibiting the RhoA/ROCK2/MLCK signaling pathway in Caco2 cells.
PloS one
Dec 26, 2024
Butyric acid (BA) can potentially enhance the function of the intestinal barrier. However, the mechanisms by which BA protects the intestinal mucosal barrier remain to be elucidated. Given that the Ras homolog gene family, member A (RhoA)/Rho-associa...
A green and efficient method for detecting nicosulfuron residues in field maize using hyperspectral imaging and deep learning.
Journal of hazardous materials
Nov 30, 2024
Accurate and rapid detection of nicosulfuron herbicide residues in field-grown maize is essential for implementing chemical remediation and optimizing spraying strategies. However, current detection methods are costly and time-consuming. This study a...
Physically informed deep neural networks for metabolite-corrected plasma input function estimation in dynamic PET imaging.
Computer methods and programs in biomedicine
Aug 20, 2024
INTRODUCTION: We propose a novel approach for the non-invasive quantification of dynamic PET imaging data, focusing on the arterial input function (AIF) without the need for invasive arterial cannulation.
Early detection of nicosulfuron toxicity and physiological prediction in maize using multi-branch deep learning models and hyperspectral imaging.
Journal of hazardous materials
May 28, 2024
The misuse of herbicides in fields can cause severe toxicity in maize, resulting in significant reductions in both yield and quality. Therefore, it is crucial to develop early and efficient methods for assessing herbicide toxicity, protecting maize p...
Effects of thienopyridine class antiplatelets on bleeding outcomes following robot-assisted radical prostatectomy.
Scientific reports
Mar 11, 2024
This study aimed to assess the effects of thienopyridine-class antiplatelet agents (including ticlopidine, clopidogrel, and prasugrel) on bleeding complications in patients who underwent robot-assisted radical prostatectomy. This cohort study used a ...
A deep learning model of tumor cell architecture elucidates response and resistance to CDK4/6 inhibitors.
Nature cancer
Mar 5, 2024
Cyclin-dependent kinase 4 and 6 inhibitors (CDK4/6is) have revolutionized breast cancer therapy. However, <50% of patients have an objective response, and nearly all patients develop resistance during therapy. To elucidate the underlying mechanisms, ...
One-pot multicomponent synthesis of novel pyridine derivatives for antidiabetic and antiproliferative activities.
Future medicinal chemistry
Jul 28, 2023
Due to the close relationship of diabetes with hypertension reported in various research, a set of pyridine derivatives with US FDA-approved drug cores were designed and integrated by artificial intelligence. Novel pyridines were designed and synth...
Artificial intelligence-based identification of octenidine as a Bcl-xL inhibitor.
Biochemical and biophysical research communications
Dec 20, 2021
Apoptosis plays an essential role in maintaining cellular homeostasis and preventing cancer progression. Bcl-xL, an anti-apoptotic protein, is an important modulator of the mitochondrial apoptosis pathway and is a promising target for anticancer ther...
Synergistic drug combinations and machine learning for drug repurposing in chordoma.
Scientific reports
Jul 31, 2020
Chordoma is a devastating rare cancer that affects one in a million people. With a mean-survival of just 6 years and no approved medicines, the primary treatments are surgery and radiation. In order to speed new medicines to chordoma patients, a drug...
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