A quick and reliable image-based AI algorithm for evaluating cellular senescence of gastric organoids.

Journal: Cancer biology & medicine
Published Date:

Abstract

OBJECTIVE: Organoids are a powerful tool with broad application prospects in biomedicine. Notably, they provide alternatives to animal models for testing potential drugs before clinical trials. However, the number of passages for which organoids maintain cellular vitality remains unclear.

Authors

  • Ruixin Yang
    Urology Section, Department of Surgery, Veterans Affairs Health Care System, Durham, NC.
  • Yutong Du
    Department of General Surgery of Ruijin Hospital, Shanghai Institute of Digestive Surgery, Shanghai Key Laboratory for Gastric Neoplasms, Shanghai Jiaotong University School of Medicine, Shanghai 200025, China.
  • Wingyan Kwan
    Department of General Surgery of Ruijin Hospital, Shanghai Institute of Digestive Surgery, Shanghai Key Laboratory for Gastric Neoplasms, Shanghai Jiaotong University School of Medicine, Shanghai 200025, China.
  • Ranlin Yan
    Department of General Surgery of Ruijin Hospital, Shanghai Institute of Digestive Surgery, Shanghai Key Laboratory for Gastric Neoplasms, Shanghai Jiaotong University School of Medicine, Shanghai 200025, China.
  • Qimeng Shi
    Department of General Surgery of Ruijin Hospital, Shanghai Institute of Digestive Surgery, Shanghai Key Laboratory for Gastric Neoplasms, Shanghai Jiaotong University School of Medicine, Shanghai 200025, China.
  • Lu Zang
    Department of Surgery, Ruijin Hospital, Shanghai Jiaotong University, School of Medicine, Shanghai, China.
  • Zhenggang Zhu
    Department of General Surgery of Ruijin Hospital, Shanghai Institute of Digestive Surgery, Shanghai Key Laboratory for Gastric Neoplasms, Shanghai Jiaotong University School of Medicine, Shanghai 200025, China.
  • Jianming Zhang
    School of Computer and Communication Engineering, Changsha University of Science and Technology, Changsha 410114, China.
  • Chen Li
    School of Computer Science and Technology, Xi'an Jiaotong University, Xi'an, Shaanxi, China.
  • Yingyan Yu
    Department of General Surgery of Ruijin Hospital, Shanghai Institute of Digestive Surgery, Shanghai Key Laboratory for Gastric Neoplasms, Shanghai Jiaotong University School of Medicine, Shanghai 200025, China.