AIMC Topic: Organoids

Clear Filters Showing 1 to 10 of 51 articles

Non-genetic neuromodulation with graphene optoelectronic actuators for disease models, stem cell maturation, and biohybrid robotics.

Nature communications Aug 20, 2025
Light can serve as a tunable trigger for neurobioengineering technologies, enabling probing, control, and enhancement of brain function with unmatched spatiotemporal precision. Yet, these technologies often require genetic or structural alterations o...
Robotics Cell Differentiation Neurons Brain Animals Optogenetics Induced Pluripotent Stem Cells Organoids Alzheimer Disease Graphite Humans
View on PubMed DOI

Prediction of the hypothalamus-pituitary organoid formation using machine learning.

Cell reports methods Aug 4, 2025
Multi-cellular organoids are self-assembly aggregates that mimic biological functions and developmental processes of many tissue types in vitro. They are widely employed for disease modeling and functional studies. Hypothalamus-pituitary organoids ca...
Cell Differentiation Pituitary Gland Hypothalamus Organoids Machine Learning Humans Animals Mice
View on PubMed DOI

Machine learning-assisted exploration of multidrug-drug administration regimens for organoid arrays.

Science advances Jul 30, 2025
Combination therapies enhance the therapeutic effect of cancer treatment; however, identifying effective interdependent doses, durations, and sequences of multidrug administration regimens is a time- and labor-intensive task. Here, we integrated mach...
Humans Machine Learning Antineoplastic Combined Chemotherapy Protocols Drug Synergism Spheroids, Cellular Neoplasms Cell Line, Tumor Organoids
View on PubMed DOI

Innovative organ-on-a-chip platforms for exploring tumorigenesis and therapy in head and neck cancer.

Journal of translational medicine Jul 16, 2025
BACKGROUND: Head and neck cancer (HNC) presents significant research challenges due to the complexity of its tumor microenvironment (TME) and the heterogeneity across different cancer subtypes. Recent advancements in three-dimensional (3D) culture mo...
Microphysiological Systems Spheroids, Cellular Organoids Tumor Microenvironment Animals Carcinogenesis Lab-On-A-Chip Devices Head and Neck Neoplasms Humans
View on PubMed DOI

Divide-and-conquer strategy with engineered ossification center organoids for rapid bone healing through developmental cell recruitment.

Nature communications Jul 4, 2025
Current approaches for bone repair predominantly target localized delivery of growth factors that are aimed at the coupling of angiogenesis and osteogenesis. However, delayed revascularization and regeneration of critical-sized bone defects are still...
Organoids Bone Regeneration Bone and Bones Fibroblasts Humans Printing, Three-Dimensional Animals Mesenchymal Stem Cells Mice Osteogenesis Tissue Engineering
View on PubMed DOI

Machine Learning-Enhanced Optimization for High-Throughput Precision in Cellular Droplet Bioprinting.

Advanced science (Weinheim, Baden-Wurttemberg, Germany) Apr 27, 2025
Organoids produce through traditional manual pipetting methods face challenges such as labor-intensive procedures and batch-to-batch variability in quality. To ensure consistent organoid production, 3D bioprinting platforms offer a more efficient alt...
Humans Machine Learning Algorithms Bioprinting Printing, Three-Dimensional Organoids
View on PubMed DOI

Artificial Intelligence-Enabled Quantitative Assessment and Intervention for Heart Inflammation Model Organoids.

Angewandte Chemie (International ed. in English) Apr 21, 2025
Inflammation plays a crucial role in progression of cardiovascular diseases (CVDs); thus, the discovery of rapid and precise analytical tools to assess inflammation related to CVDs is highly desirable for their diagnosis and therapeutic discovery. Ho...
Organoids Artificial Intelligence Inflammation Humans
View on PubMed DOI

Innovative construction and application of bile duct organoids: Unraveling the complexity of bile duct diseases and potential therapeutic strategies.

Cancer letters Mar 10, 2025
The biliary system is crucial for liver function, regulating bile production, secretion, and transport. Dysfunctions within this system can lead to various diseases, such as cholangiopathies and biliary fibrosis, which may progress from benign to mal...
Precision Medicine Animals Bile Ducts Tissue Engineering Bile Duct Diseases Humans Regenerative Medicine Organoids
View on PubMed DOI

Label-Free Detection of Biochemical Changes during Cortical Organoid Maturation via Raman Spectroscopy and Machine Learning.

Analytical chemistry Feb 24, 2025
Human cerebral organoids have become valuable tools in neurodevelopment research, holding promise for investigating neurological diseases and reducing drug development costs. However, clinical translation and large-scale production of brain organoids...
Organoids Spectrum Analysis, Raman Pluripotent Stem Cells Humans Machine Learning
View on PubMed DOI

Deliod a lightweight detection model for intestinal organoids based on deep learning.

Scientific reports Feb 11, 2025
Intestinal organoids are indispensable tools for exploring intestinal disorders. Deep learning methodologies are often employed in morphological analysis to evaluate the condition of these organoids. Nonetheless, prevailing analytical techniques face...
Organoids Humans Mice Deep Learning Intestines Image Processing, Computer-Assisted Animals
View on PubMed DOI
Popular Topics
Recent Journals