AIMC Topic: Organoids

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Machine Learning-Enhanced Optimization for High-Throughput Precision in Cellular Droplet Bioprinting.

Advanced science (Weinheim, Baden-Wurttemberg, Germany) Apr 27, 2025
Organoids produce through traditional manual pipetting methods face challenges such as labor-intensive procedures and batch-to-batch variability in quality. To ensure consistent organoid production, 3D bioprinting platforms offer a more efficient alt...
Bioprinting Organoids Algorithms Printing, Three-Dimensional Humans Machine Learning
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Artificial Intelligence-Enabled Quantitative Assessment and Intervention for Heart Inflammation Model Organoids.

Angewandte Chemie (International ed. in English) Apr 21, 2025
Inflammation plays a crucial role in progression of cardiovascular diseases (CVDs); thus, the discovery of rapid and precise analytical tools to assess inflammation related to CVDs is highly desirable for their diagnosis and therapeutic discovery. Ho...
Organoids Artificial Intelligence Humans Inflammation
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Innovative construction and application of bile duct organoids: Unraveling the complexity of bile duct diseases and potential therapeutic strategies.

Cancer letters Mar 10, 2025
The biliary system is crucial for liver function, regulating bile production, secretion, and transport. Dysfunctions within this system can lead to various diseases, such as cholangiopathies and biliary fibrosis, which may progress from benign to mal...
Precision Medicine Animals Humans Tissue Engineering Bile Duct Diseases Organoids Regenerative Medicine Bile Ducts
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Label-Free Detection of Biochemical Changes during Cortical Organoid Maturation via Raman Spectroscopy and Machine Learning.

Analytical chemistry Feb 24, 2025
Human cerebral organoids have become valuable tools in neurodevelopment research, holding promise for investigating neurological diseases and reducing drug development costs. However, clinical translation and large-scale production of brain organoids...
Pluripotent Stem Cells Organoids Machine Learning Spectrum Analysis, Raman Humans
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Deliod a lightweight detection model for intestinal organoids based on deep learning.

Scientific reports Feb 11, 2025
Intestinal organoids are indispensable tools for exploring intestinal disorders. Deep learning methodologies are often employed in morphological analysis to evaluate the condition of these organoids. Nonetheless, prevailing analytical techniques face...
Humans Animals Mice Intestines Organoids Deep Learning Image Processing, Computer-Assisted
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Protocol for functional screening of CFTR-targeted genetic therapies in patient-derived organoids using DETECTOR deep-learning-based analysis.

STAR protocols Jan 31, 2025
Here, we present a protocol for the rapid functional screening of gene editing and addition strategies in patient-derived organoids using the deep-learning-based tool DETECTOR (detection of targeted editing of cystic fibrosis transmembrane conductanc...
Cystic Fibrosis Transmembrane Conductance Regulator Deep Learning Humans Organoids Gene Editing Cystic Fibrosis Genetic Therapy
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Single-cell RNA sequencing and machine learning provide candidate drugs against drug-tolerant persister cells in colorectal cancer.

Biochimica et biophysica acta. Molecular basis of disease Jan 25, 2025
Drug resistance often stems from drug-tolerant persister (DTP) cells in cancer. These cells arise from various lineages and exhibit complex dynamics. However, effectively targeting DTP cells remains challenging. We used single-cell RNA sequencing (sc...
Adenomatous Polyposis Coli Organoids Drug Resistance, Neoplasm Humans Pyrimidinones Sequence Analysis, RNA Machine Learning Pyridones Antineoplastic Agents Colorectal Neoplasms Single-Cell Analysis
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Next-Gen Therapeutics: Pioneering Drug Discovery with iPSCs, Genomics, AI, and Clinical Trials in a Dish.

Annual review of pharmacology and toxicology Dec 17, 2024
In the high-stakes arena of drug discovery, the journey from bench to bedside is hindered by a daunting 92% failure rate, primarily due to unpredicted toxicities and inadequate therapeutic efficacy in clinical trials. The FDA Modernization Act 2.0 he...
Induced Pluripotent Stem Cells Organoids Drug Evaluation, Preclinical Clinical Trials as Topic Artificial Intelligence Drug Discovery Humans Precision Medicine Genomics Animals
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A deep learning approach to predict differentiation outcomes in hypothalamic-pituitary organoids.

Communications biology Dec 6, 2024
We use three-dimensional culture systems of human pluripotent stem cells for differentiation into pituitary organoids. Three-dimensional culture is inherently characterized by its ability to induce heterogeneous cell populations, making it difficult ...
Pluripotent Stem Cells Organoids Cell Differentiation Humans Pituitary Gland Deep Learning Hypothalamus
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ReBiA-Robotic Enabled Biological Automation: 3D Epithelial Tissue Production.

Advanced science (Weinheim, Baden-Wurttemberg, Germany) Sep 26, 2024
The Food and Drug Administration's recent decision to eliminate mandatory animal testing for drug approval marks a significant shift to alternative methods. Similarly, the European Parliament is advocating for a faster transition, reflecting public p...
Tissue Engineering Robotics Organoids Humans Automation Epithelial Cells
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