AttOmics: attention-based architecture for diagnosis and prognosis from omics data.
Journal:
Bioinformatics (Oxford, England)
Published Date:
Jun 30, 2023
Abstract
MOTIVATION: The increasing availability of high-throughput omics data allows for considering a new medicine centered on individual patients. Precision medicine relies on exploiting these high-throughput data with machine-learning models, especially the ones based on deep-learning approaches, to improve diagnosis. Due to the high-dimensional small-sample nature of omics data, current deep-learning models end up with many parameters and have to be fitted with a limited training set. Furthermore, interactions between molecular entities inside an omics profile are not patient specific but are the same for all patients.